2-(4-Chloro-phenylethynyl)-phenylamine
- CAS No.
- 221910-19-6
- Chemical Name:
- 2-(4-Chloro-phenylethynyl)-phenylamine
- Synonyms
- 2-((4-Chlorophenyl)ethynyl)aniline;2-(4-Chloro-phenylethynyl)-phenylamine;2-[2-(4-Chlorophenyl)ethynyl]benzenamine;Benzenamine, 2-[2-(4-chlorophenyl)ethynyl]-;2-((4-Chlorophenyl)ethynyl)aniline - [C57481]
- CBNumber:
- CB3840636
- Molecular Formula:
- C14H10ClN
- Molecular Weight:
- 227.69
- MDL Number:
- MFCD09029972
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-(4-Chloro-phenylethynyl)-phenylamine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS47627 | 2-((4-Chlorophenyl)ethynyl)aniline 97% | 221910-19-6 | 1g | $68 | 2026-06-04 | Buy |
| Synthonix | C57481 | 2-((4-Chlorophenyl)ethynyl)aniline 97% | 221910-19-6 | 250mg | $89 | 2026-05-06 | Buy |
| Synthonix | C57481 | 2-((4-Chlorophenyl)ethynyl)aniline 97% | 221910-19-6 | 1g | $100 | 2026-05-06 | Buy |
| aablocks | AA00BG8D | 2-((4-Chlorophenyl)ethynyl)aniline 98% | 221910-19-6 | 250mg | $52 | 2026-05-28 | Buy |
| Crysdot | CD12094811 | 2-((4-Chlorophenyl)ethynyl)aniline 97% | 221910-19-6 | 5g | $327 | 2026-05-27 | Buy |
2-(4-Chloro-phenylethynyl)-phenylamine Chemical Properties, Uses, Production
Synthesis
873-73-4
615-43-0
221910-19-6
PdCl2(PPh3)2 (88 mg, 0.125 mmol), CuI (24 mg, 0.125 mmol) and THF (5 mL) were added to an oven-dried, two-necked round-bottomed flask under standard reaction conditions. To this suspension, 2-iodoaniline (5.47 mg, 2.5 mmol) and triethylamine (702 μL, 5.0 mmol) were sequentially added. The reaction mixture was degassed by argon bubbling for 15 min. Subsequently, 4-chlorophenylacetylene (300 μL, 2.75 mmol) was added and the reaction mixture was stirred at room temperature. The progress of the reaction was monitored by thin-layer chromatography (TLC), and after complete consumption of 2-iodoaniline (about 2 h), the reaction mixture was filtered through diatomaceous earth and the solvent was removed by rotary evaporation to obtain the crude product. The crude product was further purified by column chromatography on silica gel (60-120 mesh) using ethyl acetate/hexane (1:9, v/v) as eluent, resulting in purified 2-((4-chlorophenyl)alkynyl)-aniline (400 mg, 83% yield).
References
[1] Dalton Transactions, 2017, vol. 46, # 5, p. 1539 - 1545
[2] Tetrahedron Letters, 2014, vol. 55, # 40, p. 5495 - 5498
[3] Tetrahedron, 2011, vol. 67, # 46, p. 8918 - 8924
[4] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 617 - 625
[5] Journal of Organic Chemistry, 2013, vol. 78, # 20, p. 10319 - 10328
2-(4-Chloro-phenylethynyl)-phenylamine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-(4-Chloro-phenylethynyl)-phenylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
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| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39718 | 58 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49996 | 58 |
