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4-Chlorophenylacetylene

4-Chlorophenylacetylene Structure
4-Chlorophenylacetylene structure
CAS No.
873-73-4
Chemical Name:
4-Chlorophenylacetylene
Synonyms
1-CHLORO-4-ETHYNYLBENZENE;oro-4-ethynyL;(4-Chlorophenyl)ethyne;4-CHOROPHENYLACETYLENE;p-Ethynylchlorobenzene;4-CHLOROPHENYLACETYLENE;4-Chlorophenylcaetylene;1-(4-Chlorophenyl)ethyne;(p-Chlorophenyl)acetylene;4-Ethynyl-1-chlorobenzene
CBNumber:
CB4129718
Molecular Formula:
C8H5Cl
Molecular Weight:
136.58
MDL Number:
MFCD00191917
MOL File:
873-73-4.mol
MSDS File:
SDS
Last updated:2026-01-13 11:18:41
Product description Number Pack Size Price
1-Chloro-4-ethynylbenzene 98% 206474 1g $40
1-Chloro-4-ethynylbenzene >98.0%(GC) C2670 1g $67
1-Chloro-4-ethynylbenzene >98.0%(GC) C2670 5g $203
4-Chlorophenylacetylene C5029-38F 1g $368
4-Chlorophenylacetylene C376500 10g $260
More product size
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4-Chlorophenylacetylene Properties

Melting point 45-47 °C(lit.)
Boiling point 79-82 °C (23 mmHg)
Density 1.24 g/cm3(Temp: 50 °C)
Flash point 10 °C
storage temp. Sealed in dry,2-8°C
solubility Acetone, Chloroform (Slightly), Dichloromethane, DMF, DMSO, Ethanol, Ethyl Acetate)
form Crystalline Mass
color Yellow to pale brown
Water Solubility Insoluble in water. Soluble in acetone, chloroform, dichloromethane, DMF, DMSO, ethanol, ethyl acetate, hexane, methanol,THF and toluene.
Stability Light Sensitive
InChI InChI=1S/C8H5Cl/c1-2-7-3-5-8(9)6-4-7/h1,3-6H
InChIKey LFZJRTMTKGYJRS-UHFFFAOYSA-N
SMILES C1(Cl)=CC=C(C#C)C=C1
CAS DataBase Reference 873-73-4(CAS DataBase Reference)
NIST Chemistry Reference Benzene, 1-chloro-4-ethynyl-(873-73-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H228-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  F,Xi
Risk Statements  36/37/38-11
Safety Statements  16-26-36-37/39
RIDADR  UN 1325 4.1/PG 2
WGK Germany  3
Hazard Note  Irritant/Keep Cold
HazardClass  4.1
HazardClass  FLAMMABLE
PackingGroup  Ⅱ
HS Code  29039990
Storage Class 4.1B - Flammable solid hazardous materials
Hazard Classifications Eye Irrit. 2
Flam. Sol. 1
Skin Irrit. 2
STOT SE 3
Limited Quantities 1.0 Kg (2.2 lbs)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
2 0

4-Chlorophenylacetylene price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 206474 1-Chloro-4-ethynylbenzene 98% 873-73-4 1g $40 2026-03-19 Buy
TCI Chemical C2670 1-Chloro-4-ethynylbenzene >98.0%(GC) 873-73-4 1g $67 2026-03-19 Buy
TCI Chemical C2670 1-Chloro-4-ethynylbenzene >98.0%(GC) 873-73-4 5g $203 2026-03-19 Buy
Usbiological C5029-38F 4-Chlorophenylacetylene 873-73-4 1g $368 2021-12-16 Buy
TRC C376500 4-Chlorophenylacetylene 873-73-4 10g $260 2021-12-16 Buy
Product number Packaging Price Buy
206474 1g $40 Buy
C2670 1g $67 Buy
C2670 5g $203 Buy
C5029-38F 1g $368 Buy
C376500 10g $260 Buy

4-Chlorophenylacetylene Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

4-Chlorophenylacetylene is used as pharmaceutical intermediate.

Synthesis Reference(s)

Synthesis, p. 728, 1984 DOI: 10.1055/s-1984-30947

General Description

1-Chloro-4-ethynylbenzene undergoes standard Sonogashira reaction with iodophenyl groups on the film surfaces via the formation of CC bonds.

Synthesis

9.5 g (0.04 mol) of 4-chloroiodobenzene and 4.2 g (0.05 mol) of 3-methylbutynol, 0.3 g of diphenylphosphine palladium dichloride Pd[(C6H5)3P]2Cl2, and 100 ml of triethylamine were mixed, and the mixture was allowed to mix and stir under the protection of nitrogen for 15 minutes. While keeping the mixture in nitrogen atmosphere, 180 mg of cuprous iodide was added. A precipitate was observed to form almost immediately. The mixture was stirred at room temperature for about 12 h. The mixture was diluted by adding ether (200 ml) and filtered. The resulting filtrate was removed from the filtrate by evaporation under reduced pressure to remove almost all the solvent and the residue was diluted with 150 ml of toluene. To the resulting solution 2.5 g of NaOH powder was added and heated to reflux the reaction for 4 hours. After filtration while hot, the solvent was removed from the filtrate by evaporation under reduced pressure. 4.6 g of 4-chlorophenylacetylene in the form of a waxy solid was obtained.

4-Chlorophenylacetylene Preparation Products And Raw materials

Raw materials

1,1-Dibromo-2-(4-chlorophenyl)ethene 4-(4-CHLOROPHENYL)-2-METHYL-3-BUTYN-2-OL 1-Bromo-2-(4-chlorophenyl)acetylene (4-CHLOROPHENYLETHYNYL)TRIMETHYLSILANE 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL

Preparation Products

4-Chloro-4'-hydroxybenzophenone 4'-Chloroacetophenone Propiolic acid, (p-chlorophenyl)- (8CI) 2,7-DIMETHYL-3,5-OCTADIYN-2,7-DIOL 9-(4-chlorophenyl)phenanthrene
Isoquinoline, 1-[2-(4-chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1R)- (2 - (4 - chlorobenzene) acetylene) benzaldehyde Butanedioic acid, (4-chlorophenyl)-, diMethyl ester 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone

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4-Chlorophenylacetylene Suppliers

Global( 260)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8743 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8807 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20125 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13816 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21594 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 933 58
BAYNOE CHEM CO.,LTD 		+86-21-34783353 +8615000719740 baynoe@baynoe.com CHINA 934 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shanghai UCHEM Inc. 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
HaBo Hong Kong Co., Limited. 		58
BAYNOE CHEM CO.,LTD 		58

View Lastest Price from 4-Chlorophenylacetylene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chlorophenylcaetylene pictures 2026-03-23 4-Chlorophenylcaetylene
873-73-4
 US $24.00-227.00 / g 5g 0.98 25kg Shanghai UCHEM Inc.
4-Chlorophenylacetylene pictures 2026-03-20 4-Chlorophenylacetylene
873-73-4
 US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
4-Chlorophenylacetylene pictures 2025-09-25 4-Chlorophenylacetylene
873-73-4
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

4-Chlorophenylacetylene Spectrum

4-Chlorophenylacetylene(873-73-4)1HNMR4-Chlorophenylacetylene(873-73-4)FT-IR

873-73-4(4-Chlorophenylacetylene)Related Search:

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1,2,4-Trichlorobenzene Chlorantraniliprole Difluorochloromethane p-Dichlorobenzene IMP. A (EP): CHLORPHENAMINE (USP: CHLORPHENIRAMINE)
3-CHLOROPHENYLACETYLENE 1-CHLORO-4-(PHENYLETHYNYL)BENZENE 98 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL

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(p-Chlorophenyl)acetylene p-Ethynylchlorobenzene Benzene, 1-chloro-4-ethynyl- (6CI, 7CI, 8CI, 9CI) 4-CHOROPHENYLACETYLENE (4-Chlorophenyl)ethyne 1-(4-Chlorophenyl)ethyne 4-Ethynyl-1-chlorobenzene 1-Chloro-4-ethynylbenzene,98% 1-Chloro-4-ethynylbenzene4-Chlorophenylacetylene Benzene, 1-chloro-4-ethynyl- 1-Chloro-4-ethynylbenzene, 98% 1GR 1-Chloro-4-ethynylbenzene, 98% 250MG 1-ethynyl-4-chlorobenzene oro-4-ethynyL 1-Chloro-4-ethynylbenzene, >95% 1-Chloro-4-ethynylbenzene 98% 1-CHLORO-4-ETHYNYLBENZENE 1-CHLORO-4-PHENYLACETYLENE 4'-CHLOROPHENYL ACETYLENE 4-CHLOROPHENYLACETYLENE 1-Chloro-4-ethynylbenzene> 4-Chlorophenylacetylene，98% 4-Chlorophenylcaetylene 4-Chlorophenylacetylene ISO 9001：2015 REACH 1-Chloro-4-ethynylbenzene - [C4938] 873-73-4 C8H5Cl ClC6H4CCH C8H6Cl Halogenated Hydrocarbons Organic Building Blocks Alkynyl Building Blocks Alkynyl Building Blocks Chemical Synthesis Halogenated Hydrocarbons Organic Building Blocks Aromatics Compounds Aromatics pharmacetical Pyridines