4-Chlorophenylacetylene
- CAS No.
- 873-73-4
- Chemical Name:
- 4-Chlorophenylacetylene
- Synonyms
- 1-CHLORO-4-ETHYNYLBENZENE;oro-4-ethynyL;(4-Chlorophenyl)ethyne;4-CHOROPHENYLACETYLENE;p-Ethynylchlorobenzene;4-CHLOROPHENYLACETYLENE;4-Chlorophenylcaetylene;1-(4-Chlorophenyl)ethyne;(p-Chlorophenyl)acetylene;4-Ethynyl-1-chlorobenzene
- CBNumber:
- CB4129718
- Molecular Formula:
- C8H5Cl
- Molecular Weight:
- 136.58
- MDL Number:
- MFCD00191917
- MOL File:
- 873-73-4.mol
- MSDS File:
- SDS
| Melting point | 45-47 °C(lit.) |
|---|---|
| Boiling point | 79-82 °C (23 mmHg) |
| Density | 1.24 g/cm3(Temp: 50 °C) |
| Flash point | 10 °C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetone, Chloroform (Slightly), Dichloromethane, DMF, DMSO, Ethanol, Ethyl Acetate) |
| form | Crystalline Mass |
| color | Yellow to pale brown |
| Water Solubility | Insoluble in water. Soluble in acetone, chloroform, dichloromethane, DMF, DMSO, ethanol, ethyl acetate, hexane, methanol,THF and toluene. |
| Stability | Light Sensitive |
| InChI | InChI=1S/C8H5Cl/c1-2-7-3-5-8(9)6-4-7/h1,3-6H |
| InChIKey | LFZJRTMTKGYJRS-UHFFFAOYSA-N |
| SMILES | C1(Cl)=CC=C(C#C)C=C1 |
| CAS DataBase Reference | 873-73-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-chloro-4-ethynyl-(873-73-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 16-26-36-37/39 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | FLAMMABLE | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| HS Code | 29039990 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Sol. 1 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-Chlorophenylacetylene price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 206474 | 1-Chloro-4-ethynylbenzene 98% | 873-73-4 | 1g | $40 | 2026-04-30 | Buy |
| TCI Chemical | C2670 | 1-Chloro-4-ethynylbenzene >98.0%(GC) | 873-73-4 | 1g | $67 | 2026-04-30 | Buy |
| TCI Chemical | C2670 | 1-Chloro-4-ethynylbenzene >98.0%(GC) | 873-73-4 | 5g | $203 | 2026-04-30 | Buy |
| TRC | TRC-C376500-1G | 4-Chlorophenylacetylene | 873-73-4 | 1g | $72 | 2026-06-03 | Buy |
| AstaTech | 98194 | 4'-CHLOROPHENYL ACETYLENE 98% | 873-73-4 | 5G | $27 | 2026-04-30 | Buy |
4-Chlorophenylacetylene Chemical Properties, Uses, Production
Chemical Properties
White Crystalline Solid
Uses
4-Chlorophenylacetylene is used as pharmaceutical intermediate.
Synthesis Reference(s)
Synthesis, p. 728, 1984 DOI: 10.1055/s-1984-30947
General Description
1-Chloro-4-ethynylbenzene undergoes standard Sonogashira reaction with iodophenyl groups on the film surfaces via the formation of CC bonds.
Synthesis
9.5 g (0.04 mol) of 4-chloroiodobenzene and 4.2 g (0.05 mol) of 3-methylbutynol, 0.3 g of diphenylphosphine palladium dichloride Pd[(C6H5)3P]2Cl2, and 100 ml of triethylamine were mixed, and the mixture was allowed to mix and stir under the protection of nitrogen for 15 minutes. While keeping the mixture in nitrogen atmosphere, 180 mg of cuprous iodide was added. A precipitate was observed to form almost immediately. The mixture was stirred at room temperature for about 12 h. The mixture was diluted by adding ether (200 ml) and filtered. The resulting filtrate was removed from the filtrate by evaporation under reduced pressure to remove almost all the solvent and the residue was diluted with 150 ml of toluene. To the resulting solution 2.5 g of NaOH powder was added and heated to reflux the reaction for 4 hours. After filtration while hot, the solvent was removed from the filtrate by evaporation under reduced pressure. 4.6 g of 4-chlorophenylacetylene in the form of a waxy solid was obtained.
4-Chlorophenylacetylene Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Union Medical Technology Co. Ltd. | 13120563767 | chemchen925@outlook.com | China | 624 | 58 |
| Zhengzhou HQ Material Co., Ltd. | 0371-67759225 13526468238 | sales@hqmat.com | China | 588 | 58 |
| Shanghai Jinyuanrui Pharmaceutical Technology Co., Ltd | 021-18217523 18217523428 | jinrui750315@126.com | China | 488 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 4-Chlorophenylacetylene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 4-Chlorophenylcaetylene
873-73-4
|
$24.00-227.00 | 5g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-09-02 | 4-Chlorophenylacetylene
873-73-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 4-Chlorophenylacetylene
873-73-4
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Chlorophenylcaetylene
873-73-4
- $24.00-227.00
- 0.98
- Shanghai UCHEM Inc.
-
- 4-Chlorophenylacetylene
873-73-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chlorophenylacetylene
873-73-4
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
