5-Methoxybenzofuran-3(2H)-one
- CAS No.
- 39581-55-0
- Chemical Name:
- 5-Methoxybenzofuran-3(2H)-one
- Synonyms
- AKOS BC-0911;5-METHOXY-BENZOFURAN-3-ONE;5-Nitro-3-Benzofuranone (2);5-methoxy-1-benzofuran-3-one;5-methoxybenzofuran-3(2H)-one;5-Methoxy-3(2H)-benzofuranone;3(2H)-Benzofuranone, 5-Methoxy-;5-Methoxy-1-benzofuran-3(2H)-one;1H-1,4-Diazepine,hexahydro-4-(phenylmethyl)-
- CBNumber:
- CB3840863
- Molecular Formula:
- C9H8O3
- Molecular Weight:
- 164.16
- MDL Number:
- MFCD08544410
- MOL File:
- 39581-55-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-Methoxybenzofuran-3(2H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PBA58155 | 5-Methoxy-1-benzofuran-3(2H)-one | 39581-55-0 | 2.5g | $501.5 | 2026-06-04 | Buy |
| Synthonix | M36758 | 5-Methoxybenzofuran-3(2H)-one | 39581-55-0 | 100mg | $141 | 2026-05-06 | Buy |
| Synthonix | M36758 | 5-Methoxybenzofuran-3(2H)-one | 39581-55-0 | 250mg | $154 | 2026-05-06 | Buy |
| Synthonix | M36758 | 5-Methoxybenzofuran-3(2H)-one | 39581-55-0 | 1g | $160 | 2026-05-06 | Buy |
| Synthonix | M36758 | 5-Methoxybenzofuran-3(2H)-one | 39581-55-0 | 5g | $770 | 2026-05-06 | Buy |
5-Methoxybenzofuran-3(2H)-one Chemical Properties, Uses, Production
Synthesis
5-Methoxybenzofuran-3(2H)-one is synthesised using 2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethanone as raw material by chemical reaction. The specific synthesis steps are as follows:
To an ice-cooled solution of boron trichloride (1.2 equiv., 10 mmol, 10 ml of a solution of 1M BC13 in dichloromethane) under N2-atmosphere was added dropwise a solution of J (1 g, 8 mmol,) in dichloromethane (5 ml). Then, chloroacetonitrile (0.7 g, 10 mmol, 1.2 equiv. ) was added dropwise, followed by aluminum(III) chloride (0.5 g, 4 mmol, 0.5 equiv. ) in one portion. The reaction mixture was allowed to warm up to room temperature and was stirred for 6 h. The reaction mixture was diluted with dichloromethane and quenched with IN hydrochloric acid at 0°C. After stirring for 10 min, the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with brine, dried (MgS04) and concentrated Purification by flash chromatography on silica gel (eluent: dichloromethane) afforded the desired product K (1 g, yield = 60percent). Intermediate K (0.15 g, 0.75 mmol, I equiv. ) and potassium acetate (0.22 g, 2.2 mmol, 3 equiv. ) were refluxed in ethanol (10 ml) for 1 h. After cooling, the reaction mixture was filtered and concentrated. The residue was mixed with water, and acidified with IN hydrochloric acid to pH = 1. The aqueous solution was extracted with ethyl acetate, the combined extracts were dried (MgS04), filtered and concentrated to afford the desired product L (110 mg, yield = 90 percent) as a pink solid The experimental procedures for the condensation reaction of compound L with 4-nitroaniline in acetic acid to form compound M, followed by Vilsmeier-Haack formulation and subsequent Knoevenagel condensation of the benzofuran carbaldehyde N with ethyl cyanoacetate to form compound 0, and finally, intramolecular cyclisation to compound 37 were performed using analogous procedures as exemplified in example 1 for the synthesis of compound f starting from compound a. Compound 37 was obtained as a yellow powder (30 mg, purity (LC) = 80 percent).
References
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 12, p. 5950 - 5957
[2] Patent: WO2005/111035, 2005, A1. Location in patent: Page/Page column 78-79
[3] Patent: CN107365322, 2017, A. Location in patent: Paragraph 0098; 0102
[4] Organic Letters, 2008, vol. 10, # 4, p. 573 - 576
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 3, p. 909 - 918
5-Methoxybenzofuran-3(2H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SUQIAN DEWEI CHEMICAL CO., LTD. | 025-025-58742998 18136843696 | sales@deweichem.cn | China | 171 | 58 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| Yancheng Schiemann Biological Technology Co.,Ltd | 0515-88280676; 18921872653 | sales@ximanbio.com | China | 1524 | 56 |
View Latest Price from 5-Methoxybenzofuran-3(2H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-04 | 5-Methoxy-3-Benzofuranone
39581-55-0
|
1g | 98%min | 50kgs/month | Shanghai Rlavie Technology Co ltd | ||
 |
2019-12-26 | 5-METHOXY-BENZOFURAN-3-ONE
39581-55-0
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 5-Methoxy-3-Benzofuranone
39581-55-0
- $0.00
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- 5-METHOXY-BENZOFURAN-3-ONE
39581-55-0
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
