Iodoacetic acid
- CAS No.
- 64-69-7
- Chemical Name:
- Iodoacetic acid
- Synonyms
- IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
- CBNumber:
- CB3854071
- Molecular Formula:
- C2H3IO2
- Molecular Weight:
- 185.95
- MDL Number:
- MFCD00002685
- MOL File:
- 64-69-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 79 °C |
|---|---|
| Boiling point | 208°C |
| Density | 2.2003 (estimate) |
| Flash point | 208°C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble, clear to hazy |
| form | Liquid |
| pka | 3.12(at 25℃) |
| color | faintly yellow |
| biological source | synthetic |
| Water Solubility | 600 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,5025 |
| BRN | 1739079 |
| Henry's Law Constant | 2.4×102 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C. |
| InChI | 1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5) |
| InChIKey | JDNTWHVOXJZDSN-UHFFFAOYSA-N |
| SMILES | OC(=O)CI |
| CAS DataBase Reference | 64-69-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | WF5188V710 |
| NIST Chemistry Reference | Acetic acid, iodo-(64-69-7) |
| EPA Substance Registry System | Iodoacetic acid (64-69-7) |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H314 | |||||||||
| Precautionary statements | P264-P270-P260-P280-P301+P310-P330-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P405-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,C | |||||||||
| Risk Statements | 25-35 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2923 8/PG 1 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AI3500000 | |||||||||
| F | 8-9 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Corr. 1A |
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| Hazardous Substances Data | 64-69-7(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 intravenous in dog: 45mg/kg | |||||||||
| NFPA 704 |
|
Iodoacetic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I4386 | Iodoacetic acid ≥98.0% (T) | 64-69-7 | 10g | $63.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | I4386 | Iodoacetic acid ≥98.0% (T) | 64-69-7 | 25g | $118 | 2026-04-30 | Buy |
| TRC | TRC-I685520-50G | Iodoacetic Acid | 64-69-7 | 50g | $674 | 2026-06-03 | Buy |
| TRC | TRC-I685520-1G | Iodoacetic Acid | 64-69-7 | 1g | $178 | 2026-06-03 | Buy |
| TRC | TRC-I685520-10G | Iodoacetic Acid | 64-69-7 | 10g | $376 | 2026-06-03 | Buy |
Iodoacetic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystalline powder
Uses
Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.
Uses
Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.
Definition
ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
General Description
Colorless or white crystals.
Air & Water Reactions
May be sensitive to heat, light, and air. Water soluble
Reactivity Profile
Iodoacetic acid reacts vigorously with bases and is corrosive.
Fire Hazard
Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.
Biochem/physiol Actions
Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.
Purification Methods
Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]
Iodoacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 727 | 60 |
| Shandong Mingde Biotechnology Co., Ltd | 15553348166 | m15553348166@163.com | China | 2027 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from Iodoacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Iodoacetic acid
64-69-7
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-03-20 | Iodoacetic acid
64-69-7
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Iodoacetic acid
64-69-7
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- Iodoacetic acid
64-69-7
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
