3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
- CAS No.
- 23930-37-2
- Chemical Name:
- 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
- Synonyms
- GR 2;GR-2;GR2R-140;GR-2/1574;Einecs 245-942-5;Alphadolone acetate;Aalfadolone acetate;Alphadolone 21-Acetate;21-Acetoxy-3α-hydroxy-5α-pregnane-11,20-dione;5α-PREGNAN-3α, 21-DIOL-11, 20-DIONE 21-ACETATE
- CBNumber:
- CB3884676
- Molecular Formula:
- C23H34O5
- Molecular Weight:
- 390.51306
- MDL Number:
- MFCD00200116
- MOL File:
- 23930-37-2.mol
- MSDS File:
- SDS
| Melting point | 175-177° |
|---|---|
| alpha | D26 +97° (c = 1.02 in chloroform) |
| Boiling point | 523.6±50.0 °C(Predicted) |
| Density | 1.164±0.06 g/cm3(Predicted) |
| pka | 15.04±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 00TN4GS00S |
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD158987 | 3a,21-Dihydroxy-5a-pregnane-11,20-dione 21-acetate | 23930-37-2 | 1mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD158987 | 3a,21-Dihydroxy-5a-pregnane-11,20-dione 21-acetate | 23930-37-2 | 10mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD158987 | 3a,21-Dihydroxy-5a-pregnane-11,20-dione 21-acetate | 23930-37-2 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD158987 | 3a,21-Dihydroxy-5a-pregnane-11,20-dione 21-acetate | 23930-37-2 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FD158987 | 3a,21-Dihydroxy-5a-pregnane-11,20-dione 21-acetate | 23930-37-2 | 25mg | $1142.25 | 2026-06-04 | Buy |
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Chemical Properties, Uses, Production
Uses
Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception[1].
Definition
ChEBI: Acetic acid [2-[(3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester is a corticosteroid hormone.
in vivo
Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2].
Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3].
| Animal Model: | Inbred Wistar-derived colony female rats (intramuscularly injected with 20 μg/100g oestradiol benzoate)[2] |
| Dosage: | Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate |
| Administration: | i.m. |
| Result: | Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion. |
| Animal Model: | Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)[3] |
| Dosage: | 14 mL/kg |
| Administration: | i.p.; single dosage |
| Result: | Decreased serum concentrations of LH. |
References
[1] Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-39. DOI:10.1016/S0304-3959(00)00300-6
[2] Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102(1):27-31. DOI:10.1677/joe.0.1020027
[3] Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3. DOI:10.1677/joe.0.1150221
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| Hunan Well Medicine Synthesis Technology Co., Ltd | 13574065797 18072509156 | 3781311946@qq.com | China | 43 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
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| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| GUANGZHOU TOPWORK CHEMISTRY CO.,LTD. | 020-87317062 13048089691 | 852378519@qq.com | China | 259 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
