Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy-
![Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy- Structure](CAS/20210305/GIF/1636894-46-6.gif)
- CAS No.
- 1636894-46-6
- Chemical Name:
- Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy-
- Synonyms
- KA2507;KA2507 ，S9934;Unii-VQ7NU11krm;KA2507, 10 mM in DMSO;Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy-;modulatory,KA 2507,KA-2507,colorectal,Histone deacetylases,immune,cancer,antitumor,KA2507,Inhibitor,melanoma,HDAC,inhibit
- CBNumber:
- CB39038955
- Molecular Formula:
- C16H14N6O2
- Molecular Weight:
- 322.32
- MDL Number:
- MFCD34473324
- MOL File:
- 1636894-46-6.mol
- MSDS File:
- SDS
| Density | 1.407±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 66.67 mg/mL (206.84 mM; Need ultrasonic) |
| form | Solid |
| pka | 8.77±0.10(Predicted) |
| color | White to light brown |
| FDA UNII | VQ7NU11KRM |
Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | LQC89446 | KA2507 | 1636894-46-6 | 25mg | $1382.75 | 2026-06-04 | Buy |
| Biosynth | LQC89446 | KA2507 | 1636894-46-6 | 50mg | $1923.5 | 2026-06-04 | Buy |
| ChemScene | CS-0168744 | KA2507 99.24% | 1636894-46-6 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0168744 | KA2507 99.24% | 1636894-46-6 | 10mg | $173 | 2026-06-04 | Buy |
| ChemScene | CS-0168744 | KA2507 99.24% | 1636894-46-6 | 25mg | $325 | 2026-06-04 | Buy |
Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy- Chemical Properties, Uses, Production
Uses
KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models[1].
in vivo
KA2507 (100-200 mg/kg; p.o.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model[1].
KA2507 also demonstrates antitumor efficacy in CT26 and MC38 colorectal cancer models[1].
Analysis of tumor samples also indicates modulation of biomarkers of antitumor immunity at efficacious dosing, with KA2507 administration resulting in reduced STAT3 activation (as measured by phospho-STAT3, an important suppressor of the antitumor immune response), reduced PD-L1 expression, and increased expression of MHC class I[1].
KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg)[1].
| Animal Model: | Male C57BL/6 mice, B16-F10 melanoma model[1] |
| Dosage: | 100 mg/kg, 200 mg/kg, 200 mg/kg |
| Administration: | Oral gavage, daily, for 20 days |
| Result: | Demonstrated antitumor efficacy. |
| Animal Model: | Male C57BL/6 mice[1] |
| Dosage: | 200 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration |
| Result: | Oral bioavailability (15%), Cmax (300 ng/mL). |
IC 50
HDAC6: 2.5 nM (IC50); HDAC8: 621 (IC50)
References
[1] Apostolia M Tsimberidou, et al. Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors. Clin Cancer Res. 2021 May 4. DOI:10.1158/1078-0432.CCR-21-0238
Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Yunyu Biotechnology Co., Ltd. | 15377663271 15377663271 | 941305929@qq.com | China | 150 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
