(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
methylammonium chloride Structure](CAS/GIF/38176-02-2.gif)
- CAS No.
- 38176-02-2
- Chemical Name:
- (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
- Synonyms
- R(+)-Verapamil monohydrochloride hydrate;LU 33925;NSC 632821;CCRIS 2680;R-Verapamil HCl;D7-R-Verapamil HCL;Verapamil impurity 31;Dexverapamil monohydrochloride;R(+)-Verapamil monohydrochloride;R(+)-Verapamil hydrate monohydrochloride
- CBNumber:
- CB3931684
- Molecular Formula:
- C27H41ClN2O5
- Molecular Weight:
- 509.07784
- MDL Number:
- MFCD11046028
- MOL File:
- 38176-02-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Properties
| Melting point | 129-131C |
|---|---|
| storage temp. | Refrigerator |
| solubility | H2O: >30mg/mL |
| form | powder |
| color | white |
| optical activity | [α]22/D +9.6°, c = 0.5 in ethanol(lit.) |
| Water Solubility |
H2O: >30mg/mL ethanol: soluble |
| InChIKey | ICKXRKHJKXMFLR-KFSCGDPASA-N |
| SMILES | O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
| FDA UNII | B0P742MK5O |
| UNSPSC Code | 12161501 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral |
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V106 | R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder | 38176-02-2 | 5mg | $296 | 2026-04-30 | Buy |
| Sigma-Aldrich | V106 | R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder | 38176-02-2 | 25mg | $1120 | 2026-04-30 | Buy |
| Biosynth | ID28684 | (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride | 38176-02-2 | 1mg | $476.74 | 2026-06-04 | Buy |
| Biosynth | ID28684 | (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride | 38176-02-2 | 2mg | $866.7 | 2026-06-04 | Buy |
| Biosynth | ID28684 | (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride | 38176-02-2 | 5mg | $1575.85 | 2026-06-04 | Buy |
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties, Uses, Production
Chemical Properties
Colourless solid
Uses
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Uses
R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.
Definition
ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride.
Biochem/physiol Actions
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7917 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2445 | 58 |
| Shanghai Zhen Li Biological Technology Co., Ltd | 021-16621358918; 18516310516;16621358918;13045646768 | zhenlipharma888@163.com | China | 19060 | 58 |
