(+/-)-Verapamil hydrochloride
- CAS No.
- 152-11-4
- Chemical Name:
- (+/-)-Verapamil hydrochloride
- Synonyms
- manidon;cordilox;izoptinhydrochloride;lu20175;Rositol;finoptin;Hormitol;Magotiron;Verapamil HCI;d-365hydrochloride
- CBNumber:
- CB7664827
- Molecular Formula:
- C27H39ClN2O4
- Molecular Weight:
- 491.06
- MDL Number:
- MFCD00069355
- MOL File:
- 152-11-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Verapamil hydrochloride European Pharmacopoeia (EP) Reference Standard | V0100000 | 50 mg | $175 |
| Verapamil hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | V-002 | 1mL | $39.1 |
| (±)-Verapamil, Hydrochloride A papaverine derivative that blocks Ca | 676777 | 100mg | $91.2 |
| Verapamil hydrochloride United States Pharmacopeia (USP) Reference Standard | 1711202 | 200mg | $501 |
| Verapamil Hydrochloride >98.0%(HPLC)(T) | V0118 | 5g | $57 |
| More product size | |||
| Melting point | 142 °C (dec.)(lit.) |
|---|---|
| Density | 1.0596 (rough estimate) |
| refractive index | 1.6290 (estimate) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: >30 mg/mL |
| form | solid |
| pka | 8.6(at 25℃) |
| color | white |
| Water Solubility | soluble |
| Merck | 14,9950 |
| BRN | 3647093 |
| BCS Class | 2 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
| InChIKey | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| SMILES | Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
| CAS DataBase Reference | 152-11-4(CAS DataBase Reference) |
| FDA UNII | V3888OEY5R |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H411 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-23/24/25-39/23/24/25-11 | |||||||||
| Safety Statements | 45-36/37/39-36/37-16 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YV8320000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 |
|||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 7.6, 16 i.v.; 68, 107 s.c.; 68, 67 i.p.; 163, 114 orally (Haas, Hrtfelder) | |||||||||
| NFPA 704 |
|
(+/-)-Verapamil hydrochloride price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V0100000 | Verapamil hydrochloride European Pharmacopoeia (EP) Reference Standard | 152-11-4 | 50 mg | $175 | 2026-03-19 | Buy |
| Sigma-Aldrich | V-002 | Verapamil hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 152-11-4 | 1mL | $39.1 | 2026-03-19 | Buy |
| Sigma-Aldrich | 676777 | (±)-Verapamil, Hydrochloride A papaverine derivative that blocks Ca | 152-11-4 | 100mg | $91.2 | 2026-03-19 | Buy |
| Sigma-Aldrich | 1711202 | Verapamil hydrochloride United States Pharmacopeia (USP) Reference Standard | 152-11-4 | 200mg | $501 | 2026-03-19 | Buy |
| TCI Chemical | V0118 | Verapamil Hydrochloride >98.0%(HPLC)(T) | 152-11-4 | 5g | $57 | 2026-03-19 | Buy |
(+/-)-Verapamil hydrochloride Chemical Properties,Uses,Production
Description
Verapamil HCl (152-11-4) is a clinically useful L-type calcium channel blocker.1 It is also used as an inhibitor of drug efflux pump proteins.2
Chemical Properties
white to off-white powder
Originator
Isoptin,Knoll ,W. Germany ,1963
Uses
analgesic, antipyretic
Uses
Bromhexine metabolite, sodium channel blocker, decongestent secretolytic agent for respiratory diseases
Uses
±)-Verapamil hydrochloride is a calcium channel modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the cardiac muscle cells at higher doses.
Manufacturing Process
177.2 g (1 mol) of veratryl cyanide are dissolved in 1 liter of toluene in a
three-neck flask. 42.9 g (1.1 mols) of pulverized sodium amide are added.
The mixture is heated to boiling under reflux for one hour while stirring and
excluding moisture. A solution of the base (N-methyl-N-homoveratryl)-γ-
aminochloropropane, freshly prepared from 339.2 g (1.1 mols) of the
hydrochloride, in 1.2 liters of toluene is added drop by drop into this boiling
mixture within two hours while stirring vigorously. Heating and stirring are
continued for four more hours. After cooling, the reaction mixture is poured
into 3 liters of ice water while stirring, The mixture is acidified with 20%
hydrochloric acid. The acidified aqueous layer is separated, neutralized by the
addition of sodium hydroxide solution, and rendered alkaline by the addition
of concentrated potassium carbonate solution. The precipitated oily base is
taken up in benzene. On evaporating the solvent, 402 g of the crude base are
obtained in the form of a reddish-brown, viscous oil.
The crude base is dissolved in a mixture of 550 ml of isopropanol and 650 ml
of ethyl acetate; Gaseous hydrogen chloride is introduced into the solution
until it is of weakly acidic reaction. On allowing the mixture to stand at 0°C,
365 g of α-[(N-methyl-N-homoveratryl)-γ-amino-propyl]-3,4-dimethoxyphenyl
acetonitrile hydrochloride precipitate as a slightly yellowish crystal powder of
the melting point 136°C to 139°C (corr.). Yield: 81% of the theoretical yield.
The pure, white hydrochloride melting at 140°C to 142°C (corr.) is obtained
on recrystallizing the crude salt twice from isopropanol with the addition of
decolorizing carbon. The salt is very soluble in water. The base prepared from
the hydrochloride in the form of an almost colorless, very viscous oil boils at
233°C to 235°C/0.01 mm Hg; nD25= 1.5532. Dioxalate, melting point: 123°C
to 125°C (corr.), on recrystallization from acetone and isopropanol.
61.9 g (0.15 mol) of α-[(N-methyl-N-homoveratryl)-γ-aminopropyl]-3,4-
dimethoxyphenyl acetonitrile are dissolved in 300 ml of toluene. The solution
is heated to boiling under reflux with 8.5 g (1.45 x 0.15 mols) of pulverized
sodium amide for one hour while stirring. Thereafter, a solution of 31.4 g (1.7
x 0.15 mols) of isopropyl bromide in 50 ml of toluene is added drop by drop
thereto within 90 minutes and the mixture is kept boiling for four more hours
while stirring. The cooled reaction mixture is allowed to run into 1.5 liters of
ice water and the mixture is acidified with 20% hydrochloric acid. The aqueous layer is separated and is rendered alkaline by the addition of a
solution of potassium carbonate. The base is taken up in warm benzene. The
solvent is evaporated and the residue is distilled in a vacuum. 62.6 g of α-
isopropyl-α-[(N-methyl-N-homoveratryl)-γ-aminopropy]-3,4-dimethoxyphenyl
acetonitrile are obtained in the form of a light yellow, very viscous oil. Boiling
point: 232°C to 235°C/0.01 mm Hg; n D 25 = 1.5460. Yield: 91.8% of the
theoretical yield. Hydrochloride: melting point: 139.5°C to 140.5°C (corr.), on
recrystallization from a mixture of isopropanol and ethyl acetate.
brand name
Calan (Searle); Covera (Searle); Isoptin (FSC); Isoptin (Par); Verelan (Elan).
Therapeutic Function
Coronary vasodilator, Antiarrhythmic
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Verapamil hydrochloride is a calcium channel blocker used commonly for the management of angina, supra-ventricular tachyarrhythmia, hypertension, migraine and atrial tachyarrhythmias.
Biological Activity
L-type calcium channel blocker. Vasodilator, adrenergic antagonist.
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
storage
Room temperature
References
[1] R N BROGDEN P B. Verapamil: a review of its pharmacological properties and therapeutic use in coronary artery disease.[J]. Drugs, 1996, 51 5: 792-819. DOI:10.2165/00003495-199651050-00007
[2] A R SAFA. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.[J]. The Journal of Biological Chemistry, 1987, 262 16: 7884-7888.
(+/-)-Verapamil hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi an Biohorlden Industry Trade Co Ltd | +86-18829283179 +86-13636819721 | sales@horlden.com | China | 334 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
View Lastest Price from (+/-)-Verapamil hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | (+/-)-Verapamil hydrochloride
152-11-4
|
US $87.00 / g | 10g | 99% | 10kg | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-04-21 | Verapamil hydrochloride
152-11-4
|
US $0.00-0.00 / Kg | 1Kg | 99% | 50KG | Xi an Biohorlden Industry Trade Co Ltd | |
 |
2026-04-21 | Verapamil hydrochloride
152-11-4
|
US $41.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. |
-
- (+/-)-Verapamil hydrochloride
152-11-4
- US $87.00 / g
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- Verapamil hydrochloride
152-11-4
- US $0.00-0.00 / Kg
- 99%
- Xi an Biohorlden Industry Trade Co Ltd
-
- Verapamil hydrochloride
152-11-4
- US $41.00 / mg
- 99.84%
- TargetMol Chemicals Inc.
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