5-Methoxy-2-fluorobenzyl cyanide
- CAS No.
- 672931-28-1
- Chemical Name:
- 5-Methoxy-2-fluorobenzyl cyanide
- Synonyms
- 2-Fluoro-5-methoxybenzeneacetonitrile;2-Fluoro-5-methoxyphenylacetonitrile97%;Benzeneacetonitrile, 2-fluoro-5-methoxy-;2-Fluoro-5-methoxyphenylacetonitrile 97%;2-(2-fluoro-5-Methoxyphenyl)acetonitrile;Benzeneacetonitrile, 2-fluoro-5-methoxy- (9CI);2-Fluoro-5-methoxybenzyl cyanide, (2-Fluoro-5-methoxyphenyl)acetonitrile
- CBNumber:
- CB3971792
- Molecular Formula:
- C9H8FNO
- Molecular Weight:
- 165.16
- MDL Number:
- MFCD09038466
- MOL File:
- 672931-28-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2909309090 |
5-Methoxy-2-fluorobenzyl cyanide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC48340 | 2-Fluoro-5-methoxyphenylacetonitrile 97% | 672931-28-1 | 250mg | $66 | 2026-06-04 | Buy |
| Activate Scientific | AS32637 | 5-Methoxy-2-fluorobenzylcyanide 95% | 672931-28-1 | 1g | $263 | 2026-06-04 | Buy |
| Activate Scientific | AS32637 | 5-Methoxy-2-fluorobenzylcyanide 95% | 672931-28-1 | 5g | $882 | 2026-06-04 | Buy |
| aablocks | AA0062U3 | 5-Methoxy-2-fluorobenzylcyanide 95% | 672931-28-1 | 250mg | $74 | 2026-05-28 | Buy |
| aablocks | AA0062U3 | 5-Methoxy-2-fluorobenzylcyanide 95% | 672931-28-1 | 1g | $85 | 2026-05-28 | Buy |
5-Methoxy-2-fluorobenzyl cyanide Chemical Properties,Uses,Production
Synthesis
773837-37-9
91319-42-5
672931-28-1
General procedure for the synthesis of 2-fluoro-5-methoxyphenylacetonitrile from the compound (CAS: 773837-37-9) and 2-fluoro-5-methoxybenzyl bromide: Sodium cyanide (362 mg, 7.53 mmol) was added to a solution of compound 4 (1.5 g, 6.84 mmol) in anhydrous ethanol (15 mL), and the reaction mixture was stirred for 2 hr at 85 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was concentrated to obtain the crude product. The crude product was diluted with ice water (30 mL) and extracted with ethyl acetate (2 x 50 mL). The organic layers were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by rapid chromatography on silica gel (eluent: petroleum ether/ethyl acetate, gradient gradually increased from 100/0 to 70/30) to afford compound 5 (1 g, 90% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6) δ: 7.21 (t, J = 9.2 Hz, 1H), 7.01 (dd, J = 6.1, 3.1 Hz, 1H), 6.94 (m, 1H), 4.01 (s, 2H), 3.75 (s, 3H). Mass spectrum (ESI) m/z: 166.06 [M+H]+.
References
[1] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 302-303
5-Methoxy-2-fluorobenzyl cyanide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai Jovan Biochemical Technology Co. Ltd. | +86-021-61654350 | 1245958370@qq.com | China | 2979 | 50 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
