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ChemicalBook >> CAS DataBase List >>1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- Structure
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- structure
CAS No.
2680616-96-8
Chemical Name:
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-
Synonyms
GNE-1858;GNE-1858, 10 mM in DMSO;6-[[2-(3,3-Difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]amino]-1-isopropyl-1H-pyrazolo[4,3-c]pyridine;1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-;hematopoietic,MAP4K,proliferation,T-cell,regulator,Inhibitor,GNE 1858,negative-feedback,inhibit,GNE-1858,receptor,signaling,MAPK Kinase Kinase Kinase,progenitor,GNE1858
CBNumber:
CB39835345
Molecular Formula:
C21H26F2N8
Molecular Weight:
428.48
MDL Number:
MFCD32708523
MOL File:
2680616-96-8.mol
Last updated:2025-09-20 20:09:13
Request For Quotation

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- Properties

Boiling point 623.3±65.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
pka 9.49±0.10(Predicted)
form Solid
color Light yellow to yellow

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- Chemical Properties,Uses,Production

Uses

GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].

References

[1] Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4. DOI:10.1016/j.str.2018.10.025

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- Suppliers

Global( 16)Suppliers
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Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5840 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 SY06@accelachem.com China 6537 58
Shanghai jerryxing Biomedical Technology Co., Ltd 17721492509; 17721492509 643638326@qq.com China 4999 58
Supplier Advantage
Accela ChemBio Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Accela ChemBio Co.,Ltd. 58
Shanghai jerryxing Biomedical Technology Co., Ltd 58

View Lastest Price from 1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GNE-1858 pictures 2025-09-19 GNE-1858
2680616-96-8
 US $175.00-556.00 / mg 99.36% 10g TargetMol Chemicals Inc.
GNE-1858 pictures 2025-09-19 GNE-1858
2680616-96-8
 US $175.00-556.00 / mg 99.36% 10g TargetMol Chemicals Inc.
  • GNE-1858 pictures
  • GNE-1858
    2680616-96-8
  • US $175.00-556.00 / mg
  • 99.36%
  • TargetMol Chemicals Inc.
  • GNE-1858 pictures
  • GNE-1858
    2680616-96-8
  • US $175.00-556.00 / mg
  • 99.36%
  • TargetMol Chemicals Inc.
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- GNE-1858 hematopoietic,MAP4K,proliferation,T-cell,regulator,Inhibitor,GNE 1858,negative-feedback,inhibit,GNE-1858,receptor,signaling,MAPK Kinase Kinase Kinase,progenitor,GNE1858 6-[[2-(3,3-Difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]amino]-1-isopropyl-1H-pyrazolo[4,3-c]pyridine GNE-1858, 10 mM in DMSO 2680616-96-8 C21H26F2N8