| Identification | Back Directory | [Name]
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- | [CAS]
2680616-96-8 | [Synonyms]
GNE-1858
6-[[2-(3,3-Difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]amino]-1-isopropyl-1H-pyrazolo[4,3-c]pyridine
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-
hematopoietic,MAP4K,proliferation,T-cell,regulator,Inhibitor,GNE 1858,negative-feedback,inhibit,GNE-1858,receptor,signaling,MAPK Kinase Kinase Kinase,progenitor,GNE1858 | [Molecular Formula]
C21H26F2N8 | [MDL Number]
MFCD32708523 | [MOL File]
2680616-96-8.mol | [Molecular Weight]
428.48 |
| Chemical Properties | Back Directory | [Boiling point ]
623.3±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.49±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1]. | [References]
[1] Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27(1):125-133.e4. DOI:10.1016/j.str.2018.10.025 |
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