Imazapyr acid
- CAS No.
- 81334-34-1
- Chemical Name:
- Imazapyr acid
- Synonyms
- IMAZAPYR;Imazapyr 98% TC;2-(4-Methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid;Charper;AC-243997;CL 252925;AC 252925;Imazapire;ARSENAL(R);Arsenal(TM)
- CBNumber:
- CB7121753
- Molecular Formula:
- C13H15N3O3
- Molecular Weight:
- 261.28
- MDL Number:
- MFCD00144470
- MOL File:
- 81334-34-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-173°C |
|---|---|
| Boiling point | 404.53°C (rough estimate) |
| Density | 1.1923 (rough estimate) |
| vapor pressure | 0-0Pa at 20-25℃ |
| refractive index | 1.5600 (estimate) |
| storage temp. | 0-6°C |
| pka | 1.9, 3.6(at 25℃) |
| BRN | 5442754 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application |
agriculture environmental |
| InChI | InChI=1S/C13H15N3O3/c1-7(2)13(3)12(19)15-10(16-13)9-8(11(17)18)5-4-6-14-9/h4-7H,1-3H3,(H,17,18)(H,15,16,19) |
| InChIKey | CLQMBPJKHLGMQK-UHFFFAOYSA-N |
| SMILES | C1(C2NC(=O)C(C)(C(C)C)N=2)=NC=CC=C1C(O)=O |
| LogP | -3.97-0.04 at 20℃ and pH3-9.9 |
| Dissociation constant | 1.7-11.1 at 20℃ |
| CAS DataBase Reference | 81334-34-1(CAS DataBase Reference) |
| FDA UNII | 787MX0M5A6 |
| EPA Substance Registry System | Imazapyr (81334-34-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36-52/53 |
| Safety Statements | 26-61 |
| WGK Germany | 2 |
| RTECS | US5682500 |
| HS Code | 29333990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 |
| Hazardous Substances Data | 81334-34-1(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: >5000 mg/kg; dermally in rabbits: >2000 mg/kg (Paxman) |
| REACH Registrations | Inactive |
Imazapyr acid price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 37877 | Imazapyr PESTANAL | 81334-34-1 | 100mg | $81.1 | 2026-04-30 | Buy |
| Biosynth | GDA33434 | Imazapyr | 81334-34-1 | 1g | $2926.4 | 2026-06-04 | Buy |
| Biosynth | GDA33434 | Imazapyr | 81334-34-1 | 10g | $9558 | 2026-06-04 | Buy |
| DC Chemicals | DC9015 | Imazapyr acid >98% | 81334-34-1 | 1g | $300 | 2026-05-24 | Buy |
| TRC | I268603 | Imazapyr | 81334-34-1 | 50mg | $160 | 2021-12-16 | Buy |
Imazapyr acid Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Imazapyr is an analytical standard used for proteomics research.
Definition
ChEBI: 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid is a pyridinemonocarboxylic acid that is nicotinic acid which is substituted at position 2 by a 4,5-dihydro-imidazol-2-yl group, which in turn is substituted at positions 4, 4, and 5 by isopropyl, ethyl, and oxo groups, respectively. It is a member of pyridines, a member of imidazolines, an imidazolone and a pyridinemonocarboxylic acid.
Production Methods
The commercial production of imazapyr involves the synthesis of its imidazolinone core through a series of well-controlled chemical reactions. The process typically starts with the preparation of key intermediates such as substituted pyridine or imidazole derivatives, which are then subjected to condensation reactions with carboxylic acid precursors to form the imidazolinone ring system. This core structure is further functionalised with alkyl and carboxylic acid groups to enhance its herbicidal activity and systemic mobility.
Mechanism of action
Non-selective, absorbed by foliage and rapidly translocated. Controls vegetation by interfering with an enzyme pathway. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS.
Pharmacology
Imazapyr kills plants by inhibiting acetolactate synthase (ALS) (I50 = 5 μM), which is the first common enzyme in the biosynthesis of the branched chain amino acids, valine, leucine, and isoleucine. Imazapyr is rapidly absorbed through the leaves of plants. Once it enters the plant, imazapyr rapidly translocates to the growing points and growth ceases within 1 day after herbicide application followed by chlorosis and then necrosis of the growing points. Total plant death will occur within 2 to 3 weeks after treatment.
Environmental Fate
Imazapyr is weakly to moderately adsorbed on sandy loam and silt loam soils. The Freundlich adsorption coefficient ranges from 0 to 7.8 (15). Because imazapyr is a weak acid and exists in different ionic states, soil pH has an effect on soil binding properties. The anionic form predominates at soil pH as low as 5.5, and this form bindsweakly to soil. The neutral or molecular form is important at soil pH from 4 to 6.5. This form binds to soil organic matter and clay. The cationic form is important at pH less than 4. Because the soil is a heterogeneous mixture of acid and base chemical groups, there may be sites within a particular soil that are 2 to 3 pH units higher or lower than the average pH. The cationic form will bind tightly to the lower pH components. Because of these interactions, small decreases in pH below 6 will result in large increases in binding. The half-life of imazapyr in the soil is 25–142 d (14). Imazapyr remains in the top 30 cm of the soil with low leaching potential. The degradation route of imazapyr in the soil has not been determined.
Metabolism
Plant Metabolism. The selectivity of imazapyr is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds (3). The half-life
of imazapyr in tolerant crops has not been accurately
determined. The metabolic route of imazapyr is not clear.
The parent compound can be metabolized to a tricyclic
compound (33, Fig. 15) in some species, but the primary
metabolite is an imidazopyrrolo-pyridine derivative (34,
Fig. 15). This compound does not inhibit acetolactate
synthase, the target site for the imidazolinones, and it
is immobile in the plant (4).
Animal Metabolism. Metabolism studies in the rat
showed that imazapyr is rapidly excreted in the urine (5).
There was no accumulation of imazapyr or any of its
derivatives in the liver, kidney, muscle, fat, or blood.
Toxicity evaluation
Imazapyr has shown no mutagenic or genotoxic activity in the Ames assay, mammalian cell gene mutation assay, in vitro chromosome aberration assay, in vitro unscheduled DNA synthesis (URS) assay, or the in vivo dominant lethal assay in male rats.This herbicide also has a low potential for bioaccumulation in fish.
Pesticide Type
Herbicide
Imazapyr acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Agrochem Laboratory | -- | sales@agrochemlab.com | China | 204 | 54 |
| Henan SIWEIYIN Medicines Co., Ltd. | 13072124697 18837373888 | zhanghyoffer@163.com | China | 42 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Rudong Zhongyi Chemical Co., Ltd | 13306234115 | jszyzj@zhongyichem.com | China | 36 | 60 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 | sales@shshiji.com | China | 9531 | 55 |
View Lastest Price from Imazapyr acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Imazapyr acid
81334-34-1
|
$1.30-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2024-12-24 | Imazapyr acid
81334-34-1
|
1Kg | 99.99% | 20 tons | airuikechemical co., ltd. | ||
 |
2019-12-31 | Imazapyr acid
81334-34-1
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Imazapyr acid
81334-34-1
- $1.30-32.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Imazapyr acid
81334-34-1
- 99.99%
- airuikechemical co., ltd.
-
- Imazapyr acid
81334-34-1
- $1.00
- 95-99%
- Career Henan Chemical Co
