2-Pyridineboronic acid
- CAS No.
- 197958-29-5
- Chemical Name:
- 2-Pyridineboronic acid
- Synonyms
- PYRIDIN-2-YLBORONIC ACID;2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;PYRIDINE-2-BORONIC ACID;2-PYRIDINYLBORONIC ACID;CAS:197958-29-5;2-Pyridineboronic;Pyridin-2-bronic Acid;2-PYRIDINEBORNIC ACID;2-PYRIDINEBORONIC ACID;Pyridin-2-boronic Acid
- CBNumber:
- CB4105486
- Molecular Formula:
- C5H6BNO2
- Molecular Weight:
- 122.92
- MDL Number:
- MFCD00151844
- MOL File:
- 197958-29-5.mol
- MSDS File:
- SDS
| Melting point | >300 |
|---|---|
| Boiling point | 308.8±34.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 7.79±0.53(Predicted) |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C5H6BNO2/c8-6(9)5-3-1-2-4-7-5/h1-4,8-9H |
| InChIKey | UMLDUMMLRZFROX-UHFFFAOYSA-N |
| SMILES | C1(B(O)O)=NC=CC=C1 |
| CAS DataBase Reference | 197958-29-5(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-41-37/38 | |||||||||
| Safety Statements | 26-36/37/39-39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold under -20C | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Pyridineboronic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS009263 | 2-Pyridineboronic acid Aldrich | 197958-29-5 | 100mg | $121 | 2026-04-30 | Buy |
| TRC | TRC-P991340-500MG | 2-Pyridineboronic Acid | 197958-29-5 | 500mg | $199 | 2026-06-03 | Buy |
| TRC | TRC-P991340-250MG | 2-Pyridineboronic Acid | 197958-29-5 | 250mg | $154 | 2026-06-03 | Buy |
| TRC | TRC-P991340-100MG | 2-Pyridineboronic Acid | 197958-29-5 | 100mg | $122 | 2026-06-03 | Buy |
| AstaTech | 65504 | 2-PYRIDINEBORONIC ACID 95% | 197958-29-5 | 0.25G | $10 | 2026-04-30 | Buy |
2-Pyridineboronic acid Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powder
Uses
2-Pyridineboronic Acid is used in organic synthesis as a reagent in Suzuki cross-coupling reactions, for example in the synthesis of aryl- and heteroaryl-substituted 3-benzyloxyisothiazoles and novel fluorescent 3-aryl- and 3-methyl-7-aryl-[1,2,3]triazolo[1,5-a]pyridines.
Synthesis
109-04-6
5419-55-6
197958-29-5
The general procedure for the synthesis of 2-pyridineboronic acid from 2-bromopyridine and triisopropyl borate was as follows: 1.58 g (10 mmol) of 2-bromopyridine and 3.76 g (20 mmol) of triisopropyl borate were dissolved in a solvent mixture of 14 mL of anhydrous toluene and 7 mL of THF, stirred and cooled at -30 °C. Under nitrogen protection, 6.25 mL (10 mmol) of 1.6 M n-butyllithium hexane solution was added slowly dropwise with a syringe. After the dropwise addition, the reaction mixture was continued to be stirred at -30 °C for 3 h. Subsequently, it was brought to room temperature and stirred for another 3 h. The completion of the reaction was monitored by TLC. 1 mL of concentrated hydrochloric acid was slowly added to the reaction mixture and stirred for 1 hr at room temperature before the mixture was poured into 200 mL of ice water. The pH was adjusted to 8 with saturated sodium bicarbonate solution, stirred, and extracted three times with 50 mL of dichloromethane. The organic phases were combined, washed with 100 mL of 5% brine and dried over anhydrous sodium sulfate. The desiccant was removed by filtration, the filtrate was concentrated to dryness by rotary evaporator, and the residue was purified by silica gel column chromatography to give 1.00 g of 2-pyridineboronic acid in 81% yield.
References
[1] Patent: CN107903250, 2018, A. Location in patent: Paragraph 0025; 0029; 0030; 0031
[2] Patent: CN108047215, 2018, A. Location in patent: Paragraph 0032; 0036-0038
[3] Patent: CN108047214, 2018, A. Location in patent: Paragraph 0024; 0025; 0029; 0031
[4] Patent: KR2015/121394, 2015, A. Location in patent: Paragraph 0154-0157
2-Pyridineboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai C&W New Material Co., Ltd. | 021-22062033 15921412618 | sales@c-wnewmaterial.com | China | 210 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 2-Pyridineboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Pyridineboronic acid
197958-29-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-13 | 2-Pyridineboronic acid
197958-29-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-Pyridineboronic acid
197958-29-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Pyridineboronic acid
197958-29-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Pyridineboronic acid
197958-29-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Pyridineboronic acid
197958-29-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
