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5-(2-Pyridyl)-1,2-dihydropyridin-2-one

5-(2-Pyridyl)-1,2-dihydropyridin-2-one structure

CAS No.: 381233-78-9

Chemical Name:: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one

Synonyms: [2,3'-BIPYRIDIN]-6'(1'H)-ONE;3'-bipyridin]-6'-ol;Perampanel Impurity 1;2,3'-bipyridin]-6'-ol;Pyronoprene Impurity 47;5-(2-PYRIDYL)-2-PYRIDONE;Perampanel Intermediate 1;2,3'-Bipyridin]-6'(1'H)-one;[2,3'-bipyridine]-6'(1'H)-one;5-(2-Pyridyl)pyridin-2(1H)-one

CBNumber:: CB72456451

Molecular Formula:: C10H8N2O

Molecular Weight:: 172.18

MDL Number:: MFCD11113414

MOL File:: 381233-78-9.mol

MSDS File:: SDS

Last updated:2026-09-12 18:54:50

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5-(2-Pyridyl)-1,2-dihydropyridin-2-one Properties

Melting point	71-75°C
Boiling point	434.3±45.0 °C(Predicted)
Density	1.221±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	10.85±0.10(Predicted)
form	Solid
color	White
InChI	InChI=1S/C10H8N2O/c13-10-5-4-8(7-12-10)9-3-1-2-6-11-9/h1-7H,(H,12,13)
InChIKey	NHWKTZWOSIVHOL-UHFFFAOYSA-N
SMILES	C1(C2C=CC(=O)NC=2)=NC=CC=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	29333990
REACH Registrations	Active

5-(2-Pyridyl)-1,2-dihydropyridin-2-one price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-P991805-2.5G	5-(2-Pyridyl)-1,2-dihydropyridin-2-one	381233-78-9	2.5g	$435	2026-06-03	Buy
TRC	TRC-P991805-1G	5-(2-Pyridyl)-1,2-dihydropyridin-2-one	381233-78-9	1g	$249	2026-06-03	Buy
TRC	TRC-P991805-10G	5-(2-Pyridyl)-1,2-dihydropyridin-2-one	381233-78-9	10g	$905	2026-06-03	Buy
Biosynth	FP29712	5-Pyridin-2-yl-1H-pyridin-2-one	381233-78-9	1g	$150	2026-06-04	Buy
Biosynth	FP29712	5-Pyridin-2-yl-1H-pyridin-2-one	381233-78-9	2g	$181.42	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-P991805-2.5G	2.5g	$435	Buy
TRC-P991805-1G	1g	$249	Buy
TRC-P991805-10G	10g	$905	Buy
FP29712	1g	$150	Buy
FP29712	2g	$181.42	Buy

5-(2-Pyridyl)-1,2-dihydropyridin-2-one Chemical Properties, Uses, Production

Uses

5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.

Synthesis

109-04-6

2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

1054483-78-1

381233-78-9

The general procedure for the synthesis of [2,3'-bipyridin]-6'(1'H)-ones from 2-bromopyridine and 2-hydroxypyridine-5-boronic acid pinacol ester was carried out as follows: firstly, the synthesis of [2,3'-bipyridin]-6'(1'H)-one was carried out by Suzuki coupling reaction of 2-bromopyridine (18) with 6-hydroxypyridine-3-boronic acid pinacol ester catalyzed by Pd(PPh3)4, with Na2CO3 as the base and CH3CN/H2O ( 1/1) as solvent and reacted at 75 °C to afford intermediate 20 in 70% yield. Subsequently, intermediate 20 was converted to thio analog 21 in 71% yield by reaction with P2S5 in pyridine at 120 °C. Finally, intermediate 21 was alkylated with 2-methylbenzyl bromide in DMF in the presence of K2CO3 to give the target product 22 in 76% yield. This synthetic route is also suitable for the preparation of other analogs for assessing the effect of phenyl and pyridyl substituents on the pyridazine ring.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5774 - 5777
[2] Patent: WO2013/19938, 2013, A1. Location in patent: Page/Page column 34; 35

5-(2-Pyridyl)-1,2-dihydropyridin-2-one synthesis

Synthesis of 5-(2-Pyridyl)-1,2-dihydropyridin-2-one from 6'-Methoxy-2,3'-bipyridine and 1-Butanol

5-(2-Pyridyl)-1,2-dihydropyridin-2-one Preparation Products And Raw materials

Raw materials

Propane, 1,1'-oxybis[2,2-dimethyl- 1,3-dimethyl-2,3-dihydro-2-oxopyrimidinium chloride 2,3'-Bipyridine, 6'-chloro- 2-Bromo-5-(2-pyridyl)pyridine 2-Pyridineboronic acid

2-Methoxy-5-pyridineboronic acid 2(1H)-Pyridinone, 5-acetyl- (9CI) 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-(Tributylstannyl)pyridine 6-Chloronicotinoyl chloride

6'-Methoxy-2,3'-bipyridine 1-Butanol 2,5-Dibromopyridine 2-Bromopyridine

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Preparation Products

PeraMpanel 5'-broMo-[2,3'-bipyridin]-6'(1'H)-one

5-(2-Pyridyl)-1,2-dihydropyridin-2-one Suppliers

Global Suppliers ( 206)

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan Lancent Medical Devices Co., Ltd.	18111675298	stochem@aliyun.com	China	215	58
Chengdu anman biomedical technology co., LTD	028-87689268 18113025300	yukijiangli@amanbio.com	China	116	58
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Chengdu Miracle Pharmaceutical Co., Ltd.	028-86136736 19130631884	sales@mic-pharma.com	China	346	56
Chengdu Dorher Pharmaceutical CO.,Ltd	028-64259743 19983537320	wangmin@focuspharm.com	China	498	58
NANJING WEDO PHARMATECH CO.,LTD.	15189836218	wedo-chem@huawe.com	China	240	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Waytry Pharmas Co. Ltd.	021-50728690 18101878792	sales@waytrypharms.com	China	49	57

Supplier	Advantage
Sichuan Lancent Medical Devices Co., Ltd.	58
Chengdu anman biomedical technology co., LTD	58
Shanghai YuLue Chemical Co., Ltd.	55
Chengdu Miracle Pharmaceutical Co., Ltd.	56
Chengdu Dorher Pharmaceutical CO.,Ltd	58
NANJING WEDO PHARMATECH CO.,LTD.	58
J & K SCIENTIFIC LTD.	76
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Waytry Pharmas Co. Ltd.	57

View Latest Price from 5-(2-Pyridyl)-1,2-dihydropyridin-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9	$2.00-8.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-08-08	5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9			99.0%min	200kg	Hangzhou ICH Biofarm Co., Ltd
2025-11-19	5-(2-Pyridyl)-1,2-dihydropyridin-2-one 381233-78-9		1kg	98%	25kg	Shanghai Joiny Pharmaceutical Co.,LTD

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
381233-78-9
$2.00-8.00
99%
Henan Fengda Chemical Co., Ltd

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
381233-78-9
99.0%min
Hangzhou ICH Biofarm Co., Ltd

5-(2-Pyridyl)-1,2-dihydropyridin-2-one
381233-78-9
$0.00
98%
Shanghai Joiny Pharmaceutical Co.,LTD

5-(2-Pyridyl)-1,2-dihydropyridin-2-one Spectrum

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE(381233-78-9)¹HNMR

381233-78-9 (5-(2-Pyridyl)-1,2-dihydropyridin-2-one) Related Search:

5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one 4-Hydroxypyridine 5-Bromo-2-methoxypyridine 2,5-Dibromopyridine 2-(2-cyanophenyl)benzonitrile

2-Bromobenzonitrile 1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one 3,5-Dimethoxypyridine Phenylboronic acid 2-Cyanophenylboronic acid

PeraMpanel 3,5-Dibromopyridine PeraMpanel 4-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile 5'-(2-cyanophenyl)-6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine] 1-oxide

PRMWGUBFXWROHD-MYWHSQMISA-N 6'-Methoxy-2,3'-bipyridine 2-(1,3,2-Dioxaborolan-2-yl)benzonitrile

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[2,3'-BIPYRIDIN]-6'(1'H)-ONE 5-(Pyridin-2-yl)-2(1H)-pyridone 5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one 5-(Pyridin-2-yl)pyridin-2(1H)-one 5-(2-Pyridyl)pyridin-2(1H)-one 5-pyridin-2-yl-1H-pyridin-2-one 5-(2-PYRIDYL)-2-PYRIDONE 2-Hydroxy-5-(2-pyridyl)pyridine 5-(2-pyridyl)-1,2-dihydropyridine-2-one Perampanel Impurity 1 3'-bipyridin]-6'-ol 2,3'-bipyridin]-6'-ol Perampanel Intermediate 1 2,3'-Bipyridin]-6'(1'H)-one (9CI, ACI) 2,3'-Bipyridin]-6'(1'H)-one Pyronoprene Impurity 47 [2,3'-bipyridine]-6'(1'H)-one 5-(2-Pyridyl)-1,2-dihydropyridin-2-one 381233-78-9 API