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ChemicalBook >> CAS DataBase List >>N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Structure
N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide structure
CAS No.
2695505-82-7
Chemical Name:
N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide
Synonyms
RAF-IN-1;N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide;4-Pyridinecarboxamide, N-[4-methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-
CBNumber:
CB411632056
Molecular Formula:
C26H22F3N3O4
Molecular Weight:
497.47
MDL Number:
MOL File:
2695505-82-7.mol
Last updated:2025-04-30 08:50:00
Request For Quotation

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Properties

Boiling point 644.7±55.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
pka 11.02±0.70(Predicted)

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Chemical Properties,Uses,Production

Uses

RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].

IC 50

BRafV600E: 29.4 nM (IC50); BRAFWT: 36 nM (IC50); c-Raf: 3.8 nM (IC50)

References

[1] Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040. DOI:10.1016/j.ejmech.2021.114040

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
JW & Y Pharmlab Co., Ltd. 021-64340559 13651849907; xinyu_shi@jwypharmlab.com.cn China 12035 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26627 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
JW & Y Pharmlab Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RAF-IN-1 pictures 2025-04-30 RAF-IN-1
2695505-82-7
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • RAF-IN-1 pictures
  • RAF-IN-1
    2695505-82-7
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide RAF-IN-1 4-Pyridinecarboxamide, N-[4-methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)- 2695505-82-7