4Hydroxy Tamoxifen
- CAS No.
- 82413-23-8
- Chemical Name:
- 4Hydroxy Tamoxifen
- Synonyms
- 4’-hydroxy Tamoxifen;Tamoxifen Citrate Impurity 18;4'-Hydroxy TaMoxifen (contains up to 10% E isoMer);Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen);4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol;Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-
- CBNumber:
- CB41175806
- Molecular Formula:
- C26H29NO2
- Molecular Weight:
- 387.51
- MDL Number:
- MOL File:
- 82413-23-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4’-hydroxy Tamoxifen ≥98%(maycontainupto10%ofthe(E)isomer) | 19519 | 1mg | $197 |
| 4’-hydroxy Tamoxifen ≥98%(maycontainupto10%ofthe(E)isomer) | 19519 | 5mg | $641 |
| 4’-Hydroxy Tamoxifen (contains up to 10% E isomer) | 014531 | 2.5mg | $552 |
| 4'-Hydroxytamoxifen 99.2% | CS-0086430 | 1mg | $341 |
| 4'-Hydroxytamoxifen 99.2% | CS-0086430 | 2.5mg | $682 |
| More product size | |||
| Melting point | 150-153°C |
|---|---|
| Boiling point | 514.4±50.0 °C(Predicted) |
| Density | 1.092±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Dichloromethane, Methanol (Slightly) |
| form | Solid |
| pka | 10.32±0.15(Predicted) |
| color | White to Off-White |
| Stability | Light Sensitive |
4Hydroxy Tamoxifen price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19519 | 4’-hydroxy Tamoxifen ≥98%(maycontainupto10%ofthe(E)isomer) | 82413-23-8 | 1mg | $197 | 2026-04-30 | Buy |
| Cayman Chemical | 19519 | 4’-hydroxy Tamoxifen ≥98%(maycontainupto10%ofthe(E)isomer) | 82413-23-8 | 5mg | $641 | 2026-04-30 | Buy |
| Usbiological | 014531 | 4’-Hydroxy Tamoxifen (contains up to 10% E isomer) | 82413-23-8 | 2.5mg | $552 | 2026-06-03 | Buy |
| ChemScene | CS-0086430 | 4'-Hydroxytamoxifen 99.2% | 82413-23-8 | 1mg | $341 | 2026-06-04 | Buy |
| ChemScene | CS-0086430 | 4'-Hydroxytamoxifen 99.2% | 82413-23-8 | 2.5mg | $682 | 2026-06-04 | Buy |
4Hydroxy Tamoxifen Chemical Properties,Uses,Production
Description
4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.
Chemical Properties
White Solid
Uses
A metabolite of Tamoxifen (T006000).
References
[1] ROLAND LSER . In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen[J]. European Journal of Cancer and Clinical Oncology, 1985, 21 8: Pages 985-990. DOI: 10.1016/0277-5379(85)90119-1
[2] H KIM CREWE. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4’-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.[J]. Drug Metabolism and Disposition, 2002, 32 1: 869-874. DOI: 10.1124/dmd.30.8.869
[3] H SEEGER. Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifen.[J]. Hormone and Metabolic Research, 2004, 36 5: 277-280. DOI: 10.1055/s-2004-814480
[4] MARIA E CUEVAS Tracey E L. In vitro cytotoxicity of 4’-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B.[J]. Oncology reports, 2015, 33 1: 464-470. DOI: 10.3892/or.2014.3565
[5] GIORGIA URBINATI. Therapeutic potential of new 4-hydroxy-tamoxifen-loaded pH-gradient liposomes in a multiple myeloma experimental model.[J]. Pharmaceutical Research, 2010, 27 2: 327-339. DOI: 10.1007/s11095-009-0023-z
4Hydroxy Tamoxifen Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9965 | 12 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 | 2853117764@yongstandards.com | China | 9999 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 4915 | 58 |
| Shenzhen Excellent Biomedical Technology Co., Ltd. | 0755-26050679 18318671572 | 2850803126@qq.com | China | 9992 | 58 |
View Lastest Price from 4Hydroxy Tamoxifen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | 4'-hydroxy Tamoxifen
82413-23-8
|
$415.00-1280.00 | 10g | TargetMol Chemicals Inc. |
-
- 4'-hydroxy Tamoxifen
82413-23-8
- $415.00-1280.00
- TargetMol Chemicals Inc.
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