Azetirelin
- CAS No.
- 95729-65-0
- Chemical Name:
- Azetirelin
- Synonyms
- YM-14673;Azetirelin;Azetirelina;Azetirelinum;Azetirelin (~85%);Nα-[(S)-4-Oxo-2-azetidinyl]carbonyl-L-His-L-Pro-NH2;Nα-[[(S)-4-Oxo-2-azetidinyl]carbonyl]-L-His-L-Pro-NH2;L-Prolinamide, (2S)-4-oxo-2-azetidinecarbonyl-L-histidyl-;Nα-[((S)-4-oxo-2-azetidinyl)carbonyl]-L-histidyl-L-prolineamide;1-[Nα-[[(S)-4-Oxo-2-azetidinyl]carbonyl]-L-histidyl]-L-prolinamide
- CBNumber:
- CB41178074
- Molecular Formula:
- C15H20N6O4
- Molecular Weight:
- 348.36
- MDL Number:
- MFCD00867196
- MOL File:
- 95729-65-0.mol
- MSDS File:
- SDS
| Melting point | >125°C (dec.) |
|---|---|
| Boiling point | 997.1±65.0 °C(Predicted) |
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Very Slightly, Heated) |
| form | Solid |
| pka | 13.98±0.40(Predicted) |
| color | Off-White |
| FDA UNII | 70J5AWG54Q |
Azetirelin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A817605-5MG | Azetirelin (~85%) | 95729-65-0 | 5mg | $889 | 2026-06-03 | Buy |
| TRC | TRC-A817605-2.5MG | Azetirelin (~85%) | 95729-65-0 | 2.5mg | $441 | 2026-06-03 | Buy |
| TRC | TRC-A817605-1MG | Azetirelin (~85%) | 95729-65-0 | 1mg | $205 | 2026-06-03 | Buy |
| Biosynth | VDA72965 | Azetirelin | 95729-65-0 | 5mg | $946.05 | 2026-06-05 | Buy |
| Biosynth | VDA72965 | Azetirelin | 95729-65-0 | 10mg | $1316.2 | 2026-06-05 | Buy |
Azetirelin Chemical Properties, Uses, Production
Originator
Azetirelin,ZYF Pharm Chemical
Uses
Azetirelin is a thyrotropin-releasing hormone (TRH) analogue. It demonstrated neuroprotective activity in rats.
Manufacturing Process
In 13 ml of DMF was dissolved 826.0 mg of L-histidyl-L-prolinamide 2-
hydrobromide and then 2 ml of a DMF solution of 405.0 mg of triethylamine
was added to the solution under ice-cooling. After maintaining 30 min under
ice-cooling, the precipitates thus formed were filtered off to provide L-histidyl-
L-prolinamide.
In 10 ml of DMF was dissolved 230.0 mg of (S)-2-azetidinone-4-carboxylic
acid and then 351.0 mg of N-hydroxy-1,2,3-benzotriazole and 453.0 mg of
dicyclohexylcarbodiimide were added to the solution under ice-cooling. Then,
after stirring the mixture for 15 min, the reaction was maintained for 15 min
at room temperature. The reaction mixture was ice-cooled again and 15 ml of
a DMF solution of foregoing L-histidyl-L-prolinamide was added to the reaction
mixture followed by reaction overnight at 0°C. The precipitates thus formed
were filtered off, the filtrate was concentrated to dryness, the residue was
dissolved in 10 ml of chloroform-methanol (4:1) and subjected to silica gel
column chromatography. The eluates by chloroform-methanol (7:3) were
collected and concentrated to dryness to provide 509.0 mg of crude product.
When the product was subjected to silica gel column chromatography again
and eluted by a mixture of chloroform, methanol, and aqueous ammonia
(40:10:1) to provide 394.0 mg of pure Nepsilon-[(S)-2-azetidinone-4-carbonyl]-
L-histidyl-L-prolinamide, melting point 183°-185°C (crystallization from a
small amount of methanol).
Therapeutic Function
TRH analogue
Azetirelin Preparation Products And Raw materials
Azetirelin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Nanjing Xinmeihe Pharmaceutical Co., Ltd. | 025-57672321 13739186949 | yuanming@huashineltd.com | China | 494 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 17717235263 | offer.de@lgcgroup.com | China | 38135 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from Azetirelin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-29 | Azetirelin
95729-65-0
|
$912.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- Azetirelin
95729-65-0
- $912.00
- 99.89%
- TargetMol Chemicals Inc.
