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Tolafentrine

Tolafentrine structure

CAS No.: 139308-65-9

Chemical Name:: Tolafentrine

Synonyms: Tolafentrine;Betahistine Impurity 20;rel-(-)-N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methylbenzenesulfonamide;Benzenesulfonamide, N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methyl-, rel-(-)-

CBNumber:: CB41179950

Molecular Formula:: C28H31N3O4S

Molecular Weight:: 505.63

MDL Number:

MOL File:: 139308-65-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-28 08:09:05

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Tolafentrine Properties

Melting point	>176°C (dec.)
Boiling point	624.675±65.00 °C(Press: 760.00 Torr)(predicted)
Density	1.296±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Sligthly)
form	Solid
pka	7.825±0.10(predicted)
color	Off-White to Yellow
FDA UNII	11U7K6T56X

Tolafentrine price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-T531000-5MG	Tolafentrine	139308-65-9	5mg	$1639	2026-06-03	Buy
TRC	TRC-T531000-2MG	Tolafentrine	139308-65-9	2mg	$731	2026-06-03	Buy
TRC	TRC-T531000-0.5MG	Tolafentrine	139308-65-9	0.5mg	$212	2026-06-03	Buy
Biosynth	FT28303	Tolafentrine	139308-65-9	0.5mg	$584.1	2026-06-04	Buy
Biosynth	FT28303	Tolafentrine	139308-65-9	1mg	$1038.4	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-T531000-5MG	5mg	$1639	Buy
TRC-T531000-2MG	2mg	$731	Buy
TRC-T531000-0.5MG	0.5mg	$212	Buy
FT28303	0.5mg	$584.1	Buy
FT28303	1mg	$1038.4	Buy

Tolafentrine Chemical Properties, Uses, Production

Uses

Tolafentrine is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.

Tolafentrine Preparation Products And Raw materials

Raw materials

Preparation Products

Tolafentrine Suppliers

Global Suppliers ( 16)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	57336	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44871	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TLC Pharmaceutical Standards Ltd.	18012923235 18012923235	chinasales04@tlcstandards.com.cn	China	7839	58
LGC Science (Shanghai) Ltd.	17717235263 17717235263	offer.de@lgcgroup.com	China	38135	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
BOC Sciences	65
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Energy Chemical	58
TargetMol Chemicals Inc.	58
TLC Pharmaceutical Standards Ltd.	58
LGC Science (Shanghai) Ltd.	58

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AKOS BC-0317 1-Phenyl-3,4-dihydroisoquinoline 3-(2-methylphenyl)piperidine Tolafentrine

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rel-(-)-N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methylbenzenesulfonamide Tolafentrine Benzenesulfonamide, N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methyl-, rel-(-)- Betahistine Impurity 20 139308-65-9 C28H31N3O4S Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds