Zopolrestat
- CAS No.
- 110703-94-1
- Chemical Name:
- Zopolrestat
- Synonyms
- Xedia;Alond;CP-73850;Zopalrestat;Zopolrestatum;Zopolrestat, CP-73850;Zopolrestat >=98% (HPLC);Zopolrestat, 10 mM in DMSO;BCSVCWVQNOXFGL-UHFFFAOYSA-N;3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid
- CBNumber:
- CB41180112
- Molecular Formula:
- C19H12F3N3O3S
- Molecular Weight:
- 419.38
- MDL Number:
- MFCD00865476
- MOL File:
- 110703-94-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Zopolrestat ≥98% (HPLC) | Z4527 | 10mg | $135 |
| Zopolrestat ≥98% (HPLC) | Z4527 | 50mg | $523 |
| Zopolrestat ≥98% | 29185 | 1mg | $36 |
| Zopolrestat ≥98% | 29185 | 5mg | $128 |
| Zopolrestat ≥98% | 29185 | 10mg | $236 |
| Melting point | 197-198℃ |
|---|---|
| Density | 1.58 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | pKa (dioxane/water): 5.46 (1:1); 6.38 (2:1) |
| form | powder |
| color | off-white to light brown |
| InChI | 1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27) |
| InChIKey | BCSVCWVQNOXFGL-UHFFFAOYSA-N |
| SMILES | OC(=O)CC1=NN(Cc2nc3cc(ccc3s2)C(F)(F)F)C(=O)c4ccccc14 |
| FDA UNII | 1PV3S9WP3D |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H413 | |||||||||
| Precautionary statements | P273-P301+P310+P330 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 4 |
|||||||||
| NFPA 704 |
|
Zopolrestat price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z4527 | Zopolrestat ≥98% (HPLC) | 110703-94-1 | 10mg | $135 | 2026-04-30 | Buy |
| Sigma-Aldrich | Z4527 | Zopolrestat ≥98% (HPLC) | 110703-94-1 | 50mg | $523 | 2026-04-30 | Buy |
| Cayman Chemical | 29185 | Zopolrestat ≥98% | 110703-94-1 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29185 | Zopolrestat ≥98% | 110703-94-1 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 29185 | Zopolrestat ≥98% | 110703-94-1 | 10mg | $236 | 2026-04-30 | Buy |
Zopolrestat Chemical Properties,Uses,Production
Originator
Alond,Pfizer
Uses
Antidiabetic; inhibitor (aldose reductase).
Manufacturing Process
A mixture of 2-methyl-5-trifluoromethylbenzothiazole (1 mole-equivalent), N- bromosuccinimide (1 mole-equivalent), carbon tetrachloride (700 ml) and a catalytic amount of benzoyl peroxide (0.2 g) was refluxed under irradiation by an UV lamp for 14 hours. The reaction mixture was cooled to room temperature, filtered to remove the precipitated succinimide and the filtrate was evaporated to dryness. The resulting solid was chromatographed over silica gel to obtain the 2-bromomethyl-5-trifluoromethyl-benzothiazole. To a mixture of ethyl 4-oxo-3H-phthalazin-1-ylacetate (1 mole-equivalent) and sodium hydride (50% w/w dispersion in mineral oil) in dimethylformamide (150 ml) was added 2-bromomethyl-5-trifluoromethylbenzothiazole (1 mole- equivalent) and the resulting mixture stirred at room temperature for 1 hour. This reaction mixture was poured over ice-water (500 ml); sufficient 10% HCl was added to adjust the pH to about 4.0 and the precipitated crude solid was collected. This was chromatographed over silica gel to obtain the ethyl[4-oxo- 3-(5-trifluoromethylbenzothiazol-2-yl)-3,4-dihydro-phthalazin-1-yl]acetate; MP: 134°-136°C. A solution of methyl or ethyl [4-oxo-3-(5-trifluoromethylbenzothiazol-2-yl)- 3,4-dihydrophthalazin-1-yl]acetate (1 mole-equivalent) in methanol (50 ml)
Therapeutic Function
Aldose reductase inhibitor
Biological Activity
Zopolrest at is an inhibitor of Aldose Reductase. AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
Zopolrestat Preparation Products And Raw materials
Raw materials
Preparation Products
Zopolrestat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
View Lastest Price from Zopolrestat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Zopolrestat
110703-94-1
|
$30.00-61.00 | 99.82% | 10g | TargetMol Chemicals Inc. |
-
- Zopolrestat
110703-94-1
- $30.00-61.00
- 99.82%
- TargetMol Chemicals Inc.
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