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Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-

Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- structure

CAS No.: 2490284-25-6

Chemical Name:: Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-

Synonyms: NN-390;Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-

CBNumber:: CB412054077

Molecular Formula:: C17H16F4N2O4S

Molecular Weight:: 420.38

MDL Number:

MOL File:: 2490284-25-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:18

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Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- Properties

Density	1.463±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: soluble
form	A crystalline solid
pka	8.83±0.10(Predicted)

Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	36564	NN-390 ≥98%	2490284-25-6	500μg	$62	2026-04-30	Buy
Cayman Chemical	36564	NN-390 ≥98%	2490284-25-6	1mg	$109	2026-04-30	Buy
Cayman Chemical	36564	NN-390 ≥98%	2490284-25-6	5mg	$456	2026-04-30	Buy
ChemScene	CS-0376469	NN-390	2490284-25-6	1mg	$329	2026-06-04	Buy
ChemScene	CS-0376469	NN-390	2490284-25-6	5mg	$987	2026-06-04	Buy

Product number	Packaging	Price	Buy
36564	500μg	$62	Buy
36564	1mg	$109	Buy
36564	5mg	$456	Buy
CS-0376469	1mg	$329	Buy
CS-0376469	5mg	$987	Buy

Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- Chemical Properties, Uses, Production

Uses

NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma)[1].

in vivo

NN-390 (male CD-1 mice, 20 mg/kg, IP, single dose) increases plasma stability^[1].
NN-390 can improve PAMPA (parallel artificial membrane permeability assay)-BBB (blood-brain barrier) score^[1].
Pharmacokinetic Parameters of NN-390 in male male CD-1 mice^[1].

Compound	KT-531	5a; NN-390
t_1/2 (h)	1.05	1.90
C_max (ng/mL)	493	750
AUC_last (h*ng/mL)	1576	2523
AUC_lnf (h*ng/mL)	1519	2548
AUC/D (h*ng/mL)	79	126

Animal Model:	CD-1 mice (male, n=3)^[1]
Dosage:	20 mg/kg
Administration:	IP, single dose (Pharmacokinetic Analysis)
Result:	Had a half-life of 115 min in human plasma, a 2.8-fold increase in stability.

IC 50

HDAC6: 9.8 nM (IC₅₀); HDAC3: >1 μM (IC₅₀); HDAC8: >1 μM (IC₅₀); HDAC11: >1 μM (IC₅₀); HDAC1: >5 μM (IC₅₀); HDAC2: >5 μM (IC₅₀)

References

[1] Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65(4):3193-3217. DOI:10.1021/acs.jmedchem.1c01585

Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- Suppliers

Global Suppliers ( 6)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9831	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58

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Benzamide, N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]- NN-390 2490284-25-6