Methyl 4-methoxysalicylate
- CAS No.
- 5446-02-6
- Chemical Name:
- Methyl 4-methoxysalicylate
- Synonyms
- METHYL 2-HYDROXY-4-METHOXYBENZOATE;ASISCHEM Z67646;RARECHEM AL BF 0038;4-methoxymethylsalicylate;methyl 2-hydroxy-p-anisate;METHYL 4-METHOXYSALICYLATE;Methyl P-Methoxysalicylate;Methyle4-methoxysalicylate;Methyl4-Methoxysalicylate>4-Methoxysalicylic Acid Methyl
- CBNumber:
- CB4121060
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00008424
- MOL File:
- 5446-02-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 4-methoxysalicylate 98% | 173681 | 10g | $60.6 |
| Methyl 4-Methoxysalicylate >99.0%(GC) | M1797 | 5g | $24 |
| Methyl 4-Methoxysalicylate >99.0%(GC) | M1797 | 25g | $94 |
| Methyl 4-Methoxysalicylate | TRC-M265515-50G | 50g | $127 |
| Methyl 4-Methoxysalicylate | TRC-M265515-25G | 25g | $102 |
| More product size | |||
| Melting point | 50-53 °C (lit.) |
|---|---|
| Boiling point | 134°C 7mm |
| Density | 1.1634 (rough estimate) |
| refractive index | 1.4600 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 9.38±0.10(Predicted) |
| form | Crystalline Powder or Crystals |
| color | White to light yellow |
| Water Solubility | Soluble in acetone. Insoluble in water. |
| BRN | 2691644 |
| InChI | 1S/C9H10O4/c1-12-6-3-4-7(8(10)5-6)9(11)13-2/h3-5,10H,1-2H3 |
| InChIKey | ZICRWXFGZCVTBZ-UHFFFAOYSA-N |
| SMILES | COC(=O)c1ccc(OC)cc1O |
| LogP | 2.430 (est) |
| CAS DataBase Reference | 5446-02-6(CAS DataBase Reference) |
| FDA UNII | 2R86H93L9U |
| NIST Chemistry Reference | Methyl 4-methoxysalicylate(5446-02-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 4-methoxysalicylate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 173681 | Methyl 4-methoxysalicylate 98% | 5446-02-6 | 10g | $60.6 | 2023-01-07 | Buy |
| TCI Chemical | M1797 | Methyl 4-Methoxysalicylate >99.0%(GC) | 5446-02-6 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | M1797 | Methyl 4-Methoxysalicylate >99.0%(GC) | 5446-02-6 | 25g | $94 | 2026-04-30 | Buy |
| TRC | TRC-M265515-50G | Methyl 4-Methoxysalicylate | 5446-02-6 | 50g | $127 | 2026-06-03 | Buy |
| TRC | TRC-M265515-25G | Methyl 4-Methoxysalicylate | 5446-02-6 | 25g | $102 | 2026-06-03 | Buy |
Methyl 4-methoxysalicylate Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline powder
Uses
Methyl 4-methoxysalicylate (methyl 2-hydroxy-4-methoxybenzoate) was used in the enantioselective synthesis of (+)-coriandrone A and B, two bioactive natural products.
Synthesis
121-98-2
5446-02-6
General procedure for the synthesis of methyl 4-methoxysalicylate from methyl 4-methoxybenzoate: Ru(MesCO2)(L) (p-cymene) [L=2,2'-bipyridine or 4,4'-dibromo bipyridine] (2.5 mol%), oxidizing agent (2.0 eq.), and methyl 4-methoxybenzoate (1.0 eq.) were added to a sealed tube. Subsequently, a mixture of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA) in the ratio of 0.6 mL:0.4 was added. The reaction mixture was placed in an oil bath preheated to 110 °C and stirred until the reaction was complete, and the reaction process was continuously monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched by the addition of ice water and extracted with dichloromethane. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated by rotary evaporator. Finally, the residue was purified by silica gel column chromatography to afford the target product methyl 4-methoxysalicylate.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 38, p. 3743 - 3746
Methyl 4-methoxysalicylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Methyl 4-methoxysalicylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | Methyl 4-methoxysalicylate
5446-02-6
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-06-20 | 4-methoxymethylsalicylate
5446-02-6
|
1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | ||
 |
2019-07-06 | Methyl 4-methoxysalicylate
5446-02-6
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- Methyl 4-methoxysalicylate
5446-02-6
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-methoxymethylsalicylate
5446-02-6
- $0.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Methyl 4-methoxysalicylate
5446-02-6
- $8.00
- 99%
- Career Henan Chemical Co
