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ZM 241385

ZM 241385 Structure
ZM 241385 structure
CAS No.
139180-30-6
Chemical Name:
ZM 241385
Synonyms
CS-2353;ZM 241385;ZM241385, 10 mM in DMSO;ZM 241385, A2A antagonist;ZM 241385; ZM241385; ZM-241385;Adenosine A2A Receptor Antagonist I, ZM 241385;4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENO;4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL;4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol;Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-
CBNumber:
CB4121732
Molecular Formula:
C16H15N7O2
Molecular Weight:
337.34
MDL Number:
MFCD00908394
MOL File:
139180-30-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-17 09:03:53
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ZM 241385 Properties

Density 1.59±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >15mg/mL
pka 10.03±0.15(Predicted)
form powder
color white to tan
InChI InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
InChIKey PWTBZOIUWZOPFT-UHFFFAOYSA-N
SMILES C1(O)=CC=C(CCNC2N=C(N)N3N=C(C4=CC=CO4)N=C3N=2)C=C1
FDA UNII 5NIC36BO71
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  46
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

ZM 241385 price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z0153 ZM 241385 ≥98% (HPLC) 139180-30-6 5mg $119 2026-04-30 Buy
Sigma-Aldrich Z0153 ZM 241385 ≥98% (HPLC) 139180-30-6 25mg $482 2026-04-30 Buy
Sigma-Aldrich 119149 Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). 139180-30-6 5MG $146 2026-04-30 Buy
TCI Chemical Z0042 ZM 241385 139180-30-6 10MG $137 2026-04-30 Buy
Cayman Chemical 20447 ZM 241385 ≥98% 139180-30-6 1mg $36 2026-04-30 Buy
Product number Packaging Price Buy
Z0153 5mg $119 Buy
Z0153 25mg $482 Buy
119149 5MG $146 Buy
Z0042 10MG $137 Buy
20447 1mg $36 Buy

ZM 241385 Chemical Properties, Uses, Production

Uses

ZM 241385 is a selective and potent Adenosine A2A-R antagonist.

Definition

ChEBI: 4-[2-[[7-amino-2-(2-furanyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol is a diamino-1,3,5-triazine.

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Synthesis

Tyramine

51-67-2

2-(furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine

139181-28-5

ZM 241385

139180-30-6

A reaction was carried out in acetonitrile (25 mL) with p-hydroxyphenethylamine (tyramine, 490 mg, 3.75 mmol) and 2-(furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine (250 mg, 892 μmol). The reaction mixture was stirred at room temperature for 22 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was adsorbed through diatomaceous earth and purified using column chromatography (eluent: dichloromethane/methanol, 25:75, v/v). The target product grade was collected, evaporated to dryness and subsequently recrystallized from ethyl acetate to afford 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol (100 mg, 33% yield) as a white solid, melting point: 229-231 °C (literature value: 225- 227°C). The product was analyzed and confirmed by 1H NMR, 13C NMR, high resolution mass spectrometry (HRMS) and high performance liquid chromatography (HPLC).1H NMR (400 MHz, d6-DMSO, 353 K) δ 8.91 (s, 1H), 7.92 (br s, 2H), 7.79 (m, 1H), 7.14 (br t, 1H), 7.04 (m, 3H) , 6.71 (m, 2H), 6.64 (dd, J = 3.3, 1.8 Hz, 1H), 3.49 (m, 2H), 2.78 (m, 2H).13C NMR (101 MHz, d6-DMSO) δ 161.1 (C), 159.0 (C), 155.9 (C), 155.4 (C), 150.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C). 146.1 (C), 144.1 (CH), 129.1 (CH), 115.0 (CH), 111.4 (CH), 111.2 (CH), 42.4 (CH2), 33.9 (CH2). HRMS (C16H15N7O2): Calculated value 338.1360 [M + H]+, measured value 338.1353. HPLC : tR 7.34 min, purity 98% (214 nm), 97% (254 nm).

storage

Room temperature

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 11, p. 3427 - 3433
[2] Structural Chemistry, 2013, vol. 24, # 4, p. 1241 - 1251
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 2, p. 718 - 738
[4] Molecular Pharmacology, 1995, vol. 48, # 6, p. 970 - 974
[5] Patent: US5270311, 1993, A

ZM 241385 synthesis

51-67-2
139181-28-5
139180-30-6
Synthesis of ZM 241385 from Tyramine and 2-(furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine

ZM 241385 Preparation Products And Raw materials

Raw materials

[(2-furanylcarbonyl)amino]- LUF5443 5-Furan-2-yl-3-methyl-1H-[1,2,4]triazole 2-(furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI)
Furan-2-carbohydrazide 2-Furonitrile Tyramine

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Preparation Products

ZM 241385 Suppliers

Global Suppliers ( 127)
Supplier Tel Email Country ProdList Advantage
Shanghai Jinyin Biological Technology Co., Ltd 021-20986266 18019349802 814527417@qq.com China 461 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Supplier Advantage
Shanghai Jinyin Biological Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Capot Chemical Co., Ltd 66
Ascent Scientific 60
Dalian Meilun Biotech Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
NCE Biomedical Co.,Ltd. 55
Shanghai T&W Pharmaceutical Co., Ltd. 58

View Latest Price from ZM 241385 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZM241385 pictures 2026-07-17 ZM241385
139180-30-6
 $48.00-128.00 99.69% 10g TargetMol Chemicals Inc.
ZM241385 pictures 2022-02-25 ZM241385
139180-30-6
 $100.00 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
ZM241385 pictures 2022-02-25 ZM241385
139180-30-6
 $100.00 1Kg/Bag 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
  • ZM241385 pictures
  • ZM241385
    139180-30-6
  • $48.00-128.00
  • 99.69%
  • TargetMol Chemicals Inc.
  • ZM241385 pictures
  • ZM241385
    139180-30-6
  • $100.00
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • ZM241385 pictures
  • ZM241385
    139180-30-6
  • $100.00
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

ZM 241385 Spectrum

ZM 241385(139180-30-6)1HNMR

139180-30-6 (ZM 241385) Related Search:

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ZM 447439 ZM 336372 ZM 39923 HCl ZM 306416 (3H)-ZM 241385
ZM 241385, [2-3H] 1H-1,2,4-Triazole-1-carboximidamide hydrochloride ZM 241385 7-Amino-s-triazolo[1,5-a]-s-triazine 1,3-Dimethyl-1H-1,2,4-triazol-5-amine
ZM 306416 hydrochloride

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4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENO Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]- 4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL ZM 241385 4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol CS-2353 ZM 241385; ZM241385; ZM-241385 7-amino-2-(furan-2-yl)-5-[2-(4-hydroxyphenyl)ethyl]amino-[1,2,4]triazolo[1,5-a][1,3,5]triazine ZM 241385, A2A antagonist ZM241385, 10 mM in DMSO Adenosine A2A Receptor Antagonist I, ZM 241385 139180-30-6 C16H15N7O2 Adenosine