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Maropitant citrate hydrate

Maropitant citrate hydrate Structure
Maropitant citrate hydrate structure
CAS No.
359875-09-5
Chemical Name:
Maropitant citrate hydrate
Synonyms
Maropitant citrate;2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;Maropitant Citrate Monohydrate;FEMA 2306;Maropitan citrate;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;ACIDUM CITRICUM ANHYDRICUM;Maropitant citrate hydrate
CBNumber:
CB4127749
Molecular Formula:
C38H48N2O8
Molecular Weight:
660.81
MDL Number:
MFCD02098080
MOL File:
359875-09-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-06 14:26:04
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Maropitant citrate hydrate Properties

Melting point 153-159 °C(lit.)
Flash point 100 °C
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form white to off-white crystalline powder
Water Solubility Water: 3 mg/mL (4.42 mM)
Major Application agriculture
environmental
food and beverages || microbiology
InChIKey XDZPFSKCXRGRIO-OHTRWSNQNA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|
CAS DataBase Reference 359875-09-5(CAS DataBase Reference)
FDA UNII LXN6S3999X
UNSPSC Code 41171614
NACRES NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Environment (GHS09)Corrosion (GHS05)
GHS08,GHS09,GHS05
Signal word  Danger
Hazard statements  H400-H373-H318-H410
Precautionary statements  P273-P391-P501-P273-P391-P501-P260-P314-P501-P280-P305+P351+P338-P310
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  Xi,T
Risk Statements  41-42/43-36/37/38-25
Safety Statements  26-39-45-36/37-22
RIDADR  UN 3284 6.1/PG 3
WGK Germany  1
RTECS  GE7350000
F  9
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1

Maropitant citrate hydrate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 77981 CT Supplement for microbiology 359875-09-5 5amp $163 2026-04-30 Buy
ChemScene CS-0033784 Maropitant citrate hydrate 99.19% 359875-09-5 5mg $97 2026-06-04 Buy
ChemScene CS-0033784 Maropitant citrate hydrate 99.19% 359875-09-5 10mg $162 2026-06-04 Buy
ChemScene CS-0033784 Maropitant citrate hydrate 99.19% 359875-09-5 25mg $271 2026-06-04 Buy
aablocks AA01KDNM Maropitant citrate hydrate 359875-09-5 1mg $63 2026-05-30 Buy
Product number Packaging Price Buy
77981 5amp $163 Buy
CS-0033784 5mg $97 Buy
CS-0033784 10mg $162 Buy
CS-0033784 25mg $271 Buy
AA01KDNM 1mg $63 Buy

Maropitant citrate hydrate Chemical Properties, Uses, Production

Description

Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.

Uses

Anti-emetic.

Pharmacokinetics

The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.

Veterinary Drugs and Treatments

Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.

Maropitant citrate hydrate synthesis

147116-67-4
77-92-9
359875-09-5
Synthesis of Maropitant citrate hydrate from (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-Methoxybenzyl)quinuclidin-3-aMine and Citric acid

Maropitant citrate hydrate Preparation Products And Raw materials

Raw materials

(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-Methoxybenzyl)quinuclidin-3-aMine Citric acid

Preparation Products

Maropitant citrate hydrate Suppliers

Global Suppliers ( 237)
Supplier Tel Email Country ProdList Advantage
Shandong Chuancheng Pharmaceutical Co. Ltd 06355032777 17606225562 huolong.ccph@qq.com China 20 58
Sichuan Qingmu Pharmaceutical Co., Ltd. 02887827187 sales@eastonpharma.cn China 58 60
Hubei Weideli Chemical Reagent Co., Ltd. 13429867250 13429867250 w13429867250@163.com China 1923 58
Shanghai Mixiu Chemical Co., Ltd. 18101936766 eileen@shmychem.com China 349 55
Tianjin Maitian Technology Co., Ltd 19102267946 motitech@126.com China 96 58
Hubei Weideli Chemical Reagent Co.，Ltd. 17771473825 13385289472 Z13385289472@163.com China 4664 58
Shandong Chenxi Pharmaceutical Co., Ltd. +86-531-88803416 13153166250 sales@chemedpharma.com China 153 58
Henan Yinuokai New Materials Co., Ltd 18836288690 18836288690 3810041989@qq.com China 1055 58
Shandong kelikang drug co., ltd 053-88113608 17854192669 sales07@pharmachemm.com China 149 58
Chemvon Biotechnology Co., Ltd 021-50790412 info@chemvon.com China 371 57
Supplier Advantage
Shandong Chuancheng Pharmaceutical Co. Ltd 58
Sichuan Qingmu Pharmaceutical Co., Ltd. 60
Hubei Weideli Chemical Reagent Co., Ltd. 58
Shanghai Mixiu Chemical Co., Ltd. 55
Tianjin Maitian Technology Co., Ltd 58
Hubei Weideli Chemical Reagent Co.，Ltd. 58
Shandong Chenxi Pharmaceutical Co., Ltd. 58
Henan Yinuokai New Materials Co., Ltd 58
Shandong kelikang drug co., ltd 58
Chemvon Biotechnology Co., Ltd 57

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Maropitant citrate hydrate Spectrum

Maropitant citrate hydrate(359875-09-5)1HNMR

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ACIDUM CITRICUM ANHYDRICUM B-HYDROXYTRICARBALLYLIC ACID HYDROXYTRICARBALLYLIC ACID CEFIXIM TELLURITE SUPPLEMENT CITRATE ION CHROMATOGRAPHY STANDARD CT SUPPLEMENT TELLURITE CEFIXIM SUPPLEMENT TIMTEC-BB SBB008922 4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine CJ 11972 hydrate (7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine Cefixim Tellurite Supplement, Tellurite Cefixim Supplement Maropitant Citrate,CJ-11,972,ACIDUM CITRICUM ANHYDRICUM,B-HYDROXYTRICARBALLYLIC ACID,HYDROXYTRICARBALLYLIC ACID,FEMA 2306,CEFIXIM TELLURITE SUPPLEMENT,CITRATE ION CHROMATOGRAPHY STANDARD,CT SUP Maropitant citrate hydrate ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine Maropitant citrate [USAN] (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate Maropitant Citrate USP/EP/BP (2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-... Maropitant citrate monohydrateQ: What is Maropitant citrate monohydrate Q: What is the CAS Number of Maropitant citrate monohydrate TIANFU CHEM---CT SUPPLEMENT Malopitan citrate (2S,3S)-2-Benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate hydrate (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine citrate monohydrate Shuwotini DZD9008 Pafolacianine Impurity 4 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID FEMA 2306 Maropitant citrate Maropitant Citrate Monohydrate Maropitan citrate 359875-09-5 C32H40N2OC6H8O7H2O C38H50N2O9 Al2H2O4 C23H29FN4O7 API API 359875-09-5