bruceine D
- CAS No.
- 21499-66-1
- Chemical Name:
- bruceine D
- Synonyms
- BRUCEIND;Nsc318801;Bruceine D, 10 mM in DMSO;Parasite,Notch,Apoptosis,Bruceine D,Inhibitor,inhibit;Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)-;(1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione;(1R,2R,3R,6R,8S,12S,13S,14R,15R,16S,17R)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione;(1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-Pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromen-5,10(6aH,11bH)-dione;(1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione;(1R,2S,3R,3AR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione
- CBNumber:
- CB41318443
- Molecular Formula:
- C20H26O9
- Molecular Weight:
- 410.42
- MDL Number:
- MFCD00221753
- MOL File:
- 21499-66-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 294-295℃ |
|---|---|
| Boiling point | 661.3±55.0 °C(Predicted) |
| Density | 1.60 |
| storage temp. | 2-8°C |
| solubility | DMSO: 100 mg/mL (243.65 mM) |
| pka | 11.55±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | JBDMZGKDLMGOFR-SOKPEVJONA-N |
| SMILES | [C@@]123CO[C@@]4([C@@H](O)[C@H](O)C1[C@@]1(C)[C@H](O)C(C=C(C)[C@]1([H])C[C@@]2([H])OC(=O)[C@H](O)[C@]34O)=O)C |&1:0,3,4,6,9,11,17,20,25,27,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
bruceine D price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40140 | Bruceine D ≥98% | 21499-66-1 | 1mg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 40140 | Bruceine D ≥98% | 21499-66-1 | 5mg | $180 | 2026-04-30 | Buy |
| Cayman Chemical | 40140 | Bruceine D ≥98% | 21499-66-1 | 10mg | $323 | 2026-04-30 | Buy |
| Cayman Chemical | 40140 | Bruceine D ≥98% | 21499-66-1 | 25mg | $715 | 2026-04-30 | Buy |
| Biosynth | FB145214 | Bruceine D | 21499-66-1 | 2mg | $150 | 2026-06-04 | Buy |
bruceine D Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the fruit of Brucea javanica.
Uses
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3].
Definition
ChEBI: A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.
References
[1] Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. DOI:10.1021/acs.jafc.8b06511
[2] Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205. DOI:10.1016/j.canlet.2017.06.014
[3] Yong Wang, et al. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet Parasitol. 2011 Apr 19;177(1-2):127-33. DOI:10.1016/j.vetpar.2010.11.040
bruceine D Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Bioanseis Phytochemicals Co., Ltd. | 13518187787 | 632977132@qq.com | China | 315 | 58 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Shanghai Zhanshu Chemical Technology Co., Ltd | +86-21-58589556 | China | 413 | 55 |
View Lastest Price from bruceine D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Bruceine D
21499-66-1
|
$41.00-128.00 | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-10 | bruceine D
21499-66-1
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2023-02-24 | Bruceine D
21499-66-1
|
20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Bruceine D
21499-66-1
- $41.00-128.00
- 99.99%
- TargetMol Chemicals Inc.
-
- bruceine D
21499-66-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Bruceine D
21499-66-1
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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