- Bruceine D
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- $41.00 / 1mg
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2026-03-25
- CAS:21499-66-1
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
- Bruceine D
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- $0.00 / 20mg
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2023-02-24
- CAS:21499-66-1
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Bruceine D
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- $9.80 / 1KG
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2020-01-10
- CAS:21499-66-1
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 20 tons
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| | bruceine D Basic information |
| Product Name: | bruceine D | | Synonyms: | BRUCEIND;Nsc318801;(1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione;Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)-;Parasite,Notch,Apoptosis,Bruceine D,Inhibitor,inhibit;(1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione;(1R,2S,3R,3AR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione;Bruceine D, 10 mM in DMSO | | CAS: | 21499-66-1 | | MF: | C20H26O9 | | MW: | 410.42 | | EINECS: | | | Product Categories: | | | Mol File: | 21499-66-1.mol |  |
| | bruceine D Chemical Properties |
| Melting point | 294-295℃ | | Boiling point | 661.3±55.0 °C(Predicted) | | density | 1.60 | | storage temp. | 2-8°C | | solubility | DMSO: 100 mg/mL (243.65 mM) | | pka | 11.55±0.70(Predicted) | | form | Solid | | color | White to off-white | | InChIKey | JBDMZGKDLMGOFR-SOKPEVJONA-N | | SMILES | [C@@]123CO[C@@]4([C@@H](O)[C@H](O)C1[C@@]1(C)[C@H](O)C(C=C(C)[C@]1([H])C[C@@]2([H])OC(=O)[C@H](O)[C@]34O)=O)C |&1:0,3,4,6,9,11,17,20,25,27,r| |
| | bruceine D Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the fruit of Brucea javanica. | | Uses | Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3]. | | Definition | ChEBI: A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity. | | References | [1] Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. DOI:10.1021/acs.jafc.8b06511
[2] Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205. DOI:10.1016/j.canlet.2017.06.014
[3] Yong Wang, et al. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet Parasitol. 2011 Apr 19;177(1-2):127-33. DOI:10.1016/j.vetpar.2010.11.040 |
| | bruceine D Preparation Products And Raw materials |
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