dihydroeponemycin
- CAS No.
- 126463-64-7
- Chemical Name:
- dihydroeponemycin
- Synonyms
- dihydroeponemycin;Dihydroeponemycin >=98% (HPLC);Heptanamide, N-[(1S)-1-(hydroxymethyl)-2-[[(1S)-1-[[(2R)-2-(hydroxymethyl)-2-oxiranyl]carbonyl]-3-methylbutyl]amino]-2-oxoethyl]-6-methyl-
- CBNumber:
- CB41340996
- Molecular Formula:
- C20H36N2O6
- Molecular Weight:
- 400.51
- MDL Number:
- MFCD17215971
- MOL File:
- 126463-64-7.mol
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ≥1mg/mL |
| form | powder |
| color | off-white to light tan |
| optical activity | [α]/D ±35.7° |
| InChI | 1S/C20H36N2O6/c1-13(2)7-5-6-8-17(25)21-16(10-23)19(27)22-15(9-14(3)4)18(26)20(11-24)12-28-20/h13-16,23-24H,5-12H2,1-4H3,(H,21,25)(H,22,27)/t15-,16-,20+/m0/s1 |
| InChIKey | IUDBVFIQSSOIDB-TWOQFEAHSA-N |
| SMILES | CC(C)CCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO)CO1 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
dihydroeponemycin price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D4321 | Dihydroeponemycin ≥98% (HPLC) | 126463-64-7 | 5mg | $1210 | 2026-04-30 | Buy |
| Sigma-Aldrich | D4321 | Dihydroeponemycin ≥98% (HPLC) | 126463-64-7 | 1mg | $302 | 2022-05-15 | Buy |
| Cayman Chemical | 10007805 | Dihydroeponemycin ≥98% | 126463-64-7 | 1mg | $244 | 2022-04-27 | Buy |
| Cayman Chemical | 10007805 | Dihydroeponemycin ≥98% | 126463-64-7 | 5mg | $1033 | 2022-04-27 | Buy |
| Biosynth | BFA46364 | Dihydroeponemycin | 126463-64-7 | 1mg | $577.2 | 2026-06-04 | Buy |
dihydroeponemycin Chemical Properties, Uses, Production
Description
Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity. Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.
Uses
Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis[1].
target
Proteasome
References
[1] Meng L, et al. Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Res. 1999;59(12):2798-2801. PMID:10383134
dihydroeponemycin Preparation Products And Raw materials
Raw materials
Preparation Products
dihydroeponemycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 81148925 17391631969 | 1023@dideu.com | China | 9999 | 58 |
| Supplier | Advantage |
|---|---|
| AdooQ BioScience, LLC | 58 |
| BOC Sciences | 65 |
| BOC Sciences | 58 |
| Energy Chemical | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |
