ChemicalBook >> CAS DataBase List >>2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide structure

CAS No.: 2815286-02-1

Chemical Name:: 2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide

Synonyms: 2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide

CBNumber:: CB413461641

Molecular Formula:: C23H23N11O3

Molecular Weight:: 501.5

MDL Number:

MOL File:: 2815286-02-1.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:15

Request For Quotation

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Properties

Density	1.78±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	8.12±0.10(Predicted)

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Chemical Properties, Uses, Production

Uses

mTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].

IC 50

mTOR: 0.49 nM (IC₅₀); HDAC1: 0.91 nM (IC₅₀); HDAC6: 86 nM (IC₅₀); HDAC8: 27 nM (IC₅₀)

References

[1] Mingming Zhang, et al. Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy. Bioorg Med Chem Lett. 2021 Oct 1;49:128286. DOI:10.1016/j.bmcl.2021.128286

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2996	55
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
TargetMol Chemicals Inc.	58

2815286-02-1 (2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide) Related Search:

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2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide 2815286-02-1 C23H23N11O3