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Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- structure

CAS No.: 2922269-18-7

Chemical Name:: Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-

Synonyms: Topo II/HDAC-IN-1;Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-

CBNumber:: CB413499848

Molecular Formula:: C15H16N4O3S

Molecular Weight:: 332.38

MDL Number:

MOL File:: 2922269-18-7.mol

TDS File:: TDS

Last updated:2026-04-24 14:58:15

Request For Quotation

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Properties

Density	1.55±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	9.41±0.20(Predicted)

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Chemical Properties,Uses,Production

Uses

Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis[1].

References

[1] Mengmiao Zhao, et al. Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. Eur J Med Chem.2023 Apr 5;252:115303. DOI:10.1016/j.ejmech.2023.115303

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29845	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Topo II/HDAC-IN-1 2922269-18-7