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safracin B

safracin B Structure
safracin B structure
CAS No.
87578-99-2
Chemical Name:
safracin B
Synonyms
safracin B;Antibiotic EM 5519;Antibiotic Y 16482-alpha;2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide;Propanamide, 2-amino-N-[[(6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-
CBNumber:
CB41353031
Molecular Formula:
C28H36N4O7
Molecular Weight:
540.61
MDL Number:
MFCD01939882
MOL File:
87578-99-2.mol
MSDS File:
SDS
Last updated:2026-05-28 02:56:47
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safracin B Properties

Boiling point 755.1±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to 20 mg/ml)
pka 9.75±0.70(Predicted)
form solid
color Yellow-green
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H312
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501

safracin B price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FS139275 Safracin B 87578-99-2 1g $34781.2 2026-06-04 Buy
aablocks AA01DOKI SAC-B 87578-99-2 1mg $182 2026-05-29 Buy
aablocks AA01DOKI SAC-B 87578-99-2 5mg $557 2026-05-29 Buy
American Custom Chemicals Corporation API0025385 SAFRACIN B 95.00% 87578-99-2 250MG $3072.3 2021-12-16 Buy
Product number Packaging Price Buy
FS139275 1g $34781.2 Buy
AA01DOKI 1mg $182 Buy
AA01DOKI 5mg $557 Buy
API0025385 250MG $3072.3 Buy

safracin B Chemical Properties,Uses,Production

Description

Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced byPseudomonas fluorescens.1Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2

Uses

Safracin B is a new antibiotics from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B is an antibiotic that exhibits anti-tumor properties.

in vivo

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2].
The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

References

[1] Y IKEDA. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.[J]. Journal of Antibiotics, 1983, 36 10: 1279-1283. DOI:10.7164/antibiotics.36.1279
[2] T OKUMOTO. Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice.[J]. Journal of Antibiotics, 1985, 38 6: 767-771. DOI:10.7164/antibiotics.38.767

safracin B Preparation Products And Raw materials

Raw materials

Preparation Products

safracin B Suppliers

Global( 27)Suppliers
Supplier Tel Email Country ProdList Advantage
INTERCHEMIE NANJING PHARMATECH CO., LTD 13656237714 13656237714; xiaokunfu@kyyykj.com China 297 55
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19087 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16103 58
Shanghai Jiegu Biotechnology Co., Ltd. 021-51698675 sales@jiejiegroup.com China 8195 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Fuxin Pharmaceutical 021-50872116 13391048226 contact@fuxinpharm.com China 1614 58
Hubei Chenxin Pharmaceutical Co., Ltd. 17362916295 w17362916295@163.com China 2995 58
Supplier Advantage
INTERCHEMIE NANJING PHARMATECH CO., LTD 55
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
Dideu Industries Group Limited 58
TargetMol Chemicals Inc. 58
BOC Sciences 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
Shanghai Jiegu Biotechnology Co., Ltd. 58
Zhejiang Huida Biotech Co., LTD 58
Fuxin Pharmaceutical 58
Hubei Chenxin Pharmaceutical Co., Ltd. 58

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safracin B 2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide Propanamide, 2-amino-N-[[(6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)- Antibiotic EM 5519 Antibiotic Y 16482-alpha 87578-99-2 C28H36N4O7