hepsulfam
- CAS No.
- 96892-57-8
- Chemical Name:
- hepsulfam
- Synonyms
- hepsulfam;NCI 329680;NSC-329680;ZINC01574758;7-sulfamoyloxyheptyl sulfamate;Heptane-1,7-diyl bis(sulfamate);Sulfamic acid, S,S'-1,7-heptanediyl ester;Bissulfamideoic acid 1,7-heptanediyl ester;Heptane-1,7-diyl bis(sulfamate)?, Hepsulfam;Bis(amidosulfuric acid)1,7-heptanediyl ester
- CBNumber:
- CB41378537
- Molecular Formula:
- C7H18N2O6S2
- Molecular Weight:
- 290.36
- MDL Number:
- MOL File:
- 96892-57-8.mol
- MSDS File:
- SDS
| Melting point | 94-95 °C |
|---|---|
| Boiling point | 478.2±55.0 °C(Predicted) |
| Density | 1.407±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 9.10±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | 971DU2GQ51 |
| NCI Drug Dictionary | hepsulfam |
hepsulfam Chemical Properties,Uses,Production
Uses
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC50 of 0.91 μg/mL in a panel of different tumors.
in vivo
Hepsulfam demonstrates superior in vivo activity in a large cell lung cancer xenograft and a gastric carcinoma model. The preclinical activity of hepsulfam suggests a possible role of this compound in the treatment of solid human malignancies. However, the increased bone marrow toxicity of hepsulfam as compared with busulfan might be critical for further clinical application[1].
References
[1] Berger DP, et al. Preclinical activity of hepsulfam and busulfan in solid human tumor xenografts and human bone marrow. Anticancer Drugs. 1992 Oct;3(5):531-9. DOI:10.1097/00001813-199210000-00014
[2] Pacheco DY, et al. Mechanisms of toxicity of hepsulfam in human tumor cell lines. Cancer Res. 1990 Dec 1;50(23):7555-8. PMID:2253204
hepsulfam Preparation Products And Raw materials
Raw materials
Preparation Products
hepsulfam Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Wuhan Yuxiang Medical Technology Co., Ltd. | 13971275651 | sales@whyxpharma.com | China | 1941 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1286 | 58 |
