YS 49
- CAS No.
- 132836-42-1
- Chemical Name:
- YS 49
- Synonyms
- YS 49;CS-884;YS 49;YS49;YS-49, 10 mM in DMSO;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
- CBNumber:
- CB41390234
- Molecular Formula:
- C20H20BrNO2
- Molecular Weight:
- 386.2823
- MDL Number:
- MFCD20926418
- MOL File:
- 132836-42-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: >10mg/mL |
| form | solid |
| color | White to off-white |
| Water Solubility | H2O: >10mg/mL |
| InChI | 1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2 |
| InChIKey | QHCUNMLYODPTIU-UHFFFAOYSA-N |
| SMILES | O.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
YS 49 price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y1521 | YS-49 monohydrate ≥98% (HPLC) | 132836-42-1 | 5mg | $213 | 2022-05-15 | Buy |
| Cayman Chemical | 30970 | YS-49 ≥98% | 132836-42-1 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 30970 | YS-49 ≥98% | 132836-42-1 | 5mg | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 30970 | YS-49 ≥98% | 132836-42-1 | 10mg | $418 | 2026-04-30 | Buy |
| Cayman Chemical | 30970 | YS-49 ≥98% | 132836-42-1 | 25mg | $783 | 2026-04-30 | Buy |
YS 49 Chemical Properties, Uses, Production
Biological Activity
YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.
in vitro
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells) |
| Incubation Time: | 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively . |
Western Blot Analysis
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ |
| Incubation Time: | 18 hours |
| Result: | Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
in vivo
YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>
| Animal Model: | Male Sprague Dawley rats (250-300 g) |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
| Result: | Serum NOx levels were significantly reduced. |
YS 49 Preparation Products And Raw materials
Raw materials
Preparation Products
YS 49 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 858 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
