ChemicalBook--->CAS DataBase List--->132836-42-1

132836-42-1

132836-42-1 Structure

132836-42-1 Structure
IdentificationBack Directory
[Name]

YS 49
[CAS]

132836-42-1
[Synonyms]

YS 49
CS-884
YS 49;YS49
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
[Molecular Formula]

C20H20BrNO2
[MDL Number]

MFCD16875442
[MOL File]

132836-42-1.mol
[Molecular Weight]

386.282
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: >10mg/mL
[form ]

solid
[color ]

White to off-white
[Water Solubility ]

H2O: >10mg/mL
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Hazard Codes ]

Xn,N
[Risk Statements ]

22-50
[Safety Statements ]

61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

3
Spectrum DetailBack Directory
[Spectrum Detail]

YS 49(132836-42-1)1HNMR
Hazard InformationBack Directory
[Biological Activity]

YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.
[in vitro]

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells)
Incubation Time: 18 hours
Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively .

Western Blot Analysis

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μΜ, 30 μΜ and 100 μΜ
Incubation Time: 18 hours
Result: Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.
[in vivo]

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>

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Animal Model: Male Sprague Dawley rats (250-300 g)
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 8 hours
Result: Serum NOx levels were significantly reduced.
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