7-Hydroxyneolamellarin A
- CAS No.
- 959662-26-1
- Chemical Name:
- 7-Hydroxyneolamellarin A
- Synonyms
- 7-Hydroxyneolamellarin A
- CBNumber:
- CB414245246
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
7-Hydroxyneolamellarin A Chemical Properties,Uses,Production
Uses
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].
in vivo
7-Hydroxyneolamellarin A (15 mg/kg; i.v.; BALB/c mice with 4T1 cells xenografts) inhibits tumor growth in vivo[1].
| Animal Model: | BALB/c mice with 4T1 cells xenografts[1] |
| Dosage: | 15 mg/kg |
| Administration: | Intravenous injection; every 2 days for 16 days |
| Result: | Inhibited tumor growth in vivo. |
References
[1] Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338. DOI:10.1016/j.bmcl.2021.128338
7-Hydroxyneolamellarin A Preparation Products And Raw materials
Raw materials
Preparation Products
7-Hydroxyneolamellarin A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biorbyt Ltd. | -- | info@biorbyt.com | CHINA | 6482 | 58 |
| Supplier | Advantage |
|---|---|
| Biorbyt Ltd. | 58 |