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YXG-158

YXG-158 Structure
YXG-158 structure
CAS No.
2952994-34-0
Chemical Name:
YXG-158
Synonyms
YXG-158;Benzamide, 4-fluoro-N-[(3β)-17-(4-methyl-1H-imidazol-1-yl)androsta-5,16-dien-3-yl]-
CBNumber:
CB414296642
Molecular Formula:
C30H36FN3O
Molecular Weight:
473.63
MDL Number:
MOL File:
2952994-34-0.mol
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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YXG-158 Properties

Density 1.272±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 8.404±0.70(predicted)

YXG-158 Chemical Properties, Uses, Production

Uses

YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].

References

[1] Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66(14):9972-9991. DOI:10.1021/acs.jmedchem.3c00880

YXG-158 Preparation Products And Raw materials

Raw materials

Preparation Products

YXG-158 Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from YXG-158 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YXG-158 pictures 2026-07-27 YXG-158
2952994-34-0
 10g TargetMol Chemicals Inc.
  • YXG-158 pictures
  • YXG-158
    2952994-34-0
  • TargetMol Chemicals Inc.

2952994-34-0 (YXG-158) Related Search:

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YXG-158 Benzamide, 4-fluoro-N-[(3β)-17-(4-methyl-1H-imidazol-1-yl)androsta-5,16-dien-3-yl]- 2952994-34-0