YXG-158 manufacturers
- YXG-158
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2026-07-27
- CAS:2952994-34-0
- Purity:
- Supply Ability: 10g
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| | YXG-158 Basic information |
| Product Name: | YXG-158 | | Synonyms: | YXG-158;Benzamide, 4-fluoro-N-[(3β)-17-(4-methyl-1H-imidazol-1-yl)androsta-5,16-dien-3-yl]- | | CAS: | 2952994-34-0 | | MF: | C30H36FN3O | | MW: | 473.63 | | EINECS: | | | Product Categories: | | | Mol File: | 2952994-34-0.mol |  |
| | YXG-158 Chemical Properties |
| density | 1.272±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.404±0.70(predicted) |
| | YXG-158 Usage And Synthesis |
| Uses | YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1]. | | References | [1] Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66(14):9972-9991. DOI:10.1021/acs.jmedchem.3c00880 |
| | YXG-158 Preparation Products And Raw materials |
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