2-hydroxy-6-methyl-1H-quinolin-4-one
- CAS No.
- 1677-44-7
- Chemical Name:
- 2-hydroxy-6-methyl-1H-quinolin-4-one
- Synonyms
- 6-Methylquinoline-2,4-diol;4-Hydroxy-6-methyl-2-quinolone;6-Methyl-2,4-dihydroxyquinoline;4,6-Dihydroxy-2-methylquinoline;2-hydroxy-6-methyl-1H-quinolin-4-one;4-Hydroxy-6-methyl-1H-quinolin-2-one;2(1H)-Quinolinone, 4-hydroxy-6-methyl-
- CBNumber:
- CB41456167
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD00227473
- MOL File:
- 1677-44-7.mol
- MSDS File:
- SDS
| Melting point | 342 ºC |
|---|---|
| Boiling point | 404.0±45.0 °C(Predicted) |
| Density | 1.313 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.50±1.00(Predicted) |
| Comptox DTXSID | DTXSID50715612 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-hydroxy-6-methyl-1H-quinolin-4-one price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 073413 | 6-Methyl-2,4-dihydroxyquinoline | 1677-44-7 | 250.00mg | $389 | 2026-05-18 | Buy |
| Matrix Scientific | 073413 | 6-Methyl-2,4-dihydroxyquinoline | 1677-44-7 | 1.00g | $838 | 2026-05-18 | Buy |
| Matrix Scientific | 073413 | 6-Methyl-2,4-dihydroxyquinoline | 1677-44-7 | 5.00g | $2250 | 2026-05-18 | Buy |
| Synthonix | M53933 | 6-Methyl-2,4-dihydroxyquinoline 95+% | 1677-44-7 | 100mg | $108 | 2026-05-06 | Buy |
| Synthonix | M53933 | 6-Methyl-2,4-dihydroxyquinoline 95+% | 1677-44-7 | 250mg | $116 | 2026-05-06 | Buy |
2-hydroxy-6-methyl-1H-quinolin-4-one Chemical Properties, Uses, Production
Synthesis
106-49-0
105-53-3
1677-44-7
In a dry three-necked flask, p-toluidine (5.0 g, 46.7 mmol), diethyl malonate (14 mL, 93.3 mmol) and polyphosphoric acid (22.5 mL, 140 mmol) were added sequentially. The reaction mixture was stirred at 150 °C for 3 hours. Upon completion of the reaction, the reaction system was cooled to room temperature, 500 mL of ice water was slowly added, and the pH was adjusted to 5-6 with alkali. the resulting yellow solid product was collected by filtration. The solid was dissolved in an appropriate amount of sodium hydroxide solution and filtered again to yield 7.5 g of 6-methyl-2,4-dihydroxyquinoline as a yellow solid in 92% yield.
References
[1] Patent: CN107098901, 2017, A. Location in patent: Paragraph 0082; 0083; 0084; 0085
[2] British Journal of Pharmacology, 2015, vol. 172, # 5, p. 1195 - 1221
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4467 - 4472
2-hydroxy-6-methyl-1H-quinolin-4-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29975 | 65 |
| Shanghai SunSyn Pharmaceutical Co., Ltd. | 021-18621020637 18621020637 | sales@sunsynpharma.com | China | 295 | 55 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2996 | 60 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7732 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Shanghai JingSi Biological Technology Co., Ltd | 18221840760 | 2990760589@qq.com | China | 241 | 58 |
