Dinoprostone ethanolamide
- CAS No.
- 194935-38-1
- Chemical Name:
- Dinoprostone ethanolamide
- Synonyms
- PROSTAGLANDIN E2 ETHANOLAMIDE;PGE2-EA;Dinoprostone ethanolamide;Prostaglandin E2 Ethanolamide Exclusive;Prostaglandin E2 Ethanolamide MaxSpecStandard;Prostaglandin E2 Ethanolamide Lipid Maps MS Standard;N-(2-HYDROXYETHYL)-9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-AMIDE;Prosta-5,13-dien-1-amide, 11,15-dihydroxy-N-(2-hydroxyethyl)-9-oxo-, (5Z,11α,13E,15S)-;(Z)-N-(2-hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enamide
- CBNumber:
- CB4146591
- Molecular Formula:
- C22H37NO5
- Molecular Weight:
- 395.53
- MDL Number:
- MFCD00797645
- MOL File:
- 194935-38-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 611.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.134±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility |
DMF: >100 mg/ml DMSO: >100 mg/ml Ethanol: >100 mg/mlPBS (pH 7.2): 12 mg/ml |
| form | powder |
| pka | 13.79±0.60(Predicted) |
| InChIKey | GKKWUSPPIQURFM-IGDGGSTLSA-N |
| SMILES | O[C@@H]1CC([C@H](C/C=C\CCCC(NCCO)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| WGK Germany | WGK 1 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 4 Oral Repr. 1B |
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| NFPA 704 |
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Dinoprostone ethanolamide price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14012 | Prostaglandin E2 Ethanolamide ≥98% | 194935-38-1 | 500μg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 14012 | Prostaglandin E2 Ethanolamide ≥98% | 194935-38-1 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 14012 | Prostaglandin E2 Ethanolamide ≥98% | 194935-38-1 | 5mg | $280 | 2026-04-30 | Buy |
| Cayman Chemical | 14012 | Prostaglandin E2 Ethanolamide ≥98% | 194935-38-1 | 10mg | $488 | 2026-04-30 | Buy |
| Cayman Chemical | 10007212 | Prostaglandin E2 Ethanolamide MaxSpec? Standard ≥95% | 194935-38-1 | 100μg | $68 | 2023-06-20 | Buy |
Dinoprostone ethanolamide Chemical Properties,Uses,Production
Description
Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; ) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively). PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes. Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.
Uses
Prostaglandin E2 Ethanolamide-d4 is the isotope labelled analogue of Prostaglandin E2 Ethanolamide, an analogue of Prostaglandin E2 (P838610). Prostaglandin E2 is most common and most biologically potent of mammalian prostaglandins.
Definition
ChEBI: Prostaglandin E2 ethanolamide is a prostanoid.
References
[1] KEVIN R KOZAK. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.[J]. The Journal of Biological Chemistry, 2002, 277 47: 44877-44885. DOI: 10.1074/jbc.m206788200
[2] TONG LIU. Intercellular transfer of the cellular prion protein.[J]. The Journal of Biological Chemistry, 2002, 277 49: 47671-47678. DOI: 10.1074/jbc.m207458200
[3] M. COSTABILE . Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins: A structure function analysis[J]. Prostaglandins, leukotrienes, and essential fatty acids, 2017, 122: Pages 7-15. DOI: 10.1016/j.plefa.2017.06.010
[4] GUANGBI LI. Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes.[J]. Journal of Pharmacology and Experimental Therapeutics, 2016, 358 1: 61-70. DOI: 10.1124/jpet.116.233239
[5] LAUREN L. NICOTRA. Prostaglandin ethanolamides attenuate damage in a human explant colitis model[J]. Prostaglandins & other lipid mediators, 2013, 100: Pages 22-29. DOI: 10.1016/j.prostaglandins.2013.01.003
[6] ROBYN RICHIE-JANNETTA . Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2α glyceryl esters in RAW 264.7 cells and H1819 cells[J]. Prostaglandins & other lipid mediators, 2010, 92 1: Pages 19-24. DOI: 10.1016/j.prostaglandins.2010.01.003
Dinoprostone ethanolamide Preparation Products And Raw materials
Raw materials
Preparation Products
Dinoprostone ethanolamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54738 | 58 |
