4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide
![4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide Structure](CAS/GIF/170569-88-7.gif)
- CAS No.
- 170569-88-7
- Chemical Name:
- 4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide
- Synonyms
- Mavacoxib;Trocoxil;PHA 739521;Mavacoxibd;Mavacoxib (PHA-739521);Mavacoxib, 10 mM in DMSO;Cyclooxygenase,Inhibitor,Mavacoxib,inhibit,COX;4-[5-(4-Fluoro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide;4-[5-(4-Fluorophenyl)-3-trifluoroMethyl-1H-pyrazol-1-yl] benzenesulfonaMide;4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide
- CBNumber:
- CB41479083
- Molecular Formula:
- C16H11F4N3O2S
- Molecular Weight:
- 385.34
- MDL Number:
- MOL File:
- 170569-88-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 167-169°C |
|---|---|
| Boiling point | 519.8±60.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.67±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Beige |
| FDA UNII | YFT7X7SR77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H373-H412 |
| Precautionary statements | P260-P314-P501-P273-P501-P201-P202-P281-P308+P313-P405-P501 |
4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0068402 | Mavacoxib 99.04% | 170569-88-7 | 5mg | $48 | 2026-06-04 | Buy |
| ChemScene | CS-0068402 | Mavacoxib 99.04% | 170569-88-7 | 10mg | $71 | 2026-06-04 | Buy |
| ChemScene | CS-0068402 | Mavacoxib 99.04% | 170569-88-7 | 25mg | $144 | 2026-06-04 | Buy |
| ChemScene | CS-0068402 | Mavacoxib 99.04% | 170569-88-7 | 50mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0068402 | Mavacoxib 99.04% | 170569-88-7 | 100mg | $325 | 2026-06-04 | Buy |
4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide Chemical Properties, Uses, Production
Synthesis
To a 250 ml three-necked flask, ethyl trifluoroacetate (13.60 g, 0.0958 mol), ethanol (20 ml), and a methanol solution of 28.4% sodium methoxide (16.50 g, 0.0868 mol) were added sequentially. Then, 4-fluoroacetophenone (10.00 g, 0.0725 mol) was added dropwise while stirring. After the addition was complete, the reaction solution was heated to 10–15 °C and reacted for 2.5 hours. Then, acetic acid (6.54 g, 0.109 mol) was added dropwise. After the addition was complete, 4-aminosulfonylphenylhydrazine hydrochloride was slowly added. The reaction solution was then reacted at 15 °C for 2 hours. The reaction solution was cooled to 5 °C and then the pH was adjusted to 7 with 50% sodium hydroxide. Ethanol (37 ml) and water (31 ml) were added, and the temperature was raised to 30 °C. Water (32 ml) was slowly added to the reaction solution.
The reaction solution was cooled to 5°C, filtered, and the filter cake was washed twice with 50% ethanol-water solution (v/v, 50 g). The filter cake was vacuum dried to give 20.109 g of the final product, with a yield of 72.0%.Uses
Mavacoxib is a long-acting COX-2 Inhibitor and is developed as a veterinary drug used to treat pain and inflammation with degenerative joint disease for dogs.
Uses
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE is a long-acting COX-2 Inhibitor and is developed as a veterinary drug used to treat pain and inflammation with degenerative joint disease for dogs.
Definition
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and 4-fluorophenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in vete inary medicine to treat pain and inflammation in dogs with degenerative joint disease.
4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 409 | 57 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
View Latest Price from 4-[5-(4-Fluorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzene-1-sulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE USP/EP/BP pictures](/ProductImageEN/2021-06/Small/e2bc0530-287a-427b-b8b0-fb6287bcaab4.jpg) |
2026-08-20 | 4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE USP/EP/BP
170569-88-7
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-27 | Mavacoxib
170569-88-7
|
$35.00-108.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- 4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE USP/EP/BP
170569-88-7
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Mavacoxib
170569-88-7
- $35.00-108.00
- 99.90%
- TargetMol Chemicals Inc.
