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ChemicalBook >> CAS DataBase List >>4-(Benzyloxy)-3,5-dimethoxybenzaldehyde

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Structure
4-(Benzyloxy)-3,5-dimethoxybenzaldehyde structure
CAS No.
6527-32-8
Chemical Name:
4-(Benzyloxy)-3,5-dimethoxybenzaldehyde
Synonyms
3,5-dimethoxy-4-phenylmethoxybenzaldehyde;Benzaldehyde, 3,5-dimethoxy-4-(phenylmethoxy)-
CBNumber:
CB41489576
Molecular Formula:
C16H16O4
Molecular Weight:
272.3
MDL Number:
MFCD00088987
MOL File:
6527-32-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:22
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4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Properties

Melting point 63 °C(Solv: ethanol (64-17-5))
Boiling point 423.4±40.0 °C(Predicted)
Density 1.164±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth GAA52732 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde 6527-32-8 5g $354 2026-06-04 Buy
aablocks AA00EKKG 4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE 98% 6527-32-8 1g $32 2026-05-28 Buy
aablocks AA00EKKG 4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE 98% 6527-32-8 5g $98 2026-05-28 Buy
aablocks AA00EKKG 4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE 98% 6527-32-8 10g $176 2026-05-28 Buy
ACHEMBLOCK P36817 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde 95% 6527-32-8 5G $150 2026-05-27 Buy
Product number Packaging Price Buy
GAA52732 5g $354 Buy
AA00EKKG 1g $32 Buy
AA00EKKG 5g $98 Buy
AA00EKKG 10g $176 Buy
P36817 5G $150 Buy

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Chemical Properties, Uses, Production

Synthesis

Benzyl bromide

100-39-0

Syringaldehyde

134-96-3

4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE

6527-32-8

General procedure for the synthesis of 4-benzyloxy-3,5-dimethoxybenzaldehyde (5'-1) from benzyl bromide and butyraldehyde: Butyraldehyde (6.0 g, 32.9 mmol) and benzyl bromide (5.9 mL, 49.4 mmol) were dissolved in 70 mL of tetrahydrofuran (THF), and were added in batches to a solution containing potassium hydroxide (3.69 g, 65.8 mmol) in a 40mL of aqueous solution. A catalytic amount of tetrabutylammonium hydrogensulfate (Bu4NHSO4, 0.56 g, 1.6 mmol) was then added and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, it was extracted with dichloromethane (CH2Cl2), the organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. Purification by silica gel column chromatography (cyclohexane/ethyl acetate, 85:15) afforded 4-benzyloxy-3,5-dimethoxybenzaldehyde (5'-1, 8.43 g, 31.0 mmol, 94% yield) in white solid form. The molecular formula of the compound is C16H16O4 and the molecular weight is 272.3 g-mol1. The analytical data are in agreement with those reported in the literature (Bennett C.J., Caldwell S.T., McPhail D.B., Morrice P.C., Duthie G.G., Hartley R.C., Bioorg. Med. Chem. 2004, 12, 2079-2098).

References

[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 14, p. 3410 - 3413
[2] Patent: US2015/73158, 2015, A1. Location in patent: Page/Page column 0026; 0027
[3] Australian Journal of Chemistry, 1988, vol. 41, # 6, p. 919 - 933
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 15, p. 2498 - 2513
[5] Australian Journal of Chemistry, 1991, vol. 44, # 9, p. 1307 - 1333

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Benzyl bromide Syringaldehyde Tetrahydrofuran Water Potassium hydroxide

Preparation Products

Phenol, 4-(3-aminopropyl)-2,6-dimethoxy- Ethyl 3-(4-(benzyloxy)-3,5-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Suppliers

Global Suppliers ( 62)
Supplier Tel Email Country ProdList Advantage
Shanghai Winherb Medical Technology Co., Ltd. 17301719108 13341702378 winherb@126.com China 1245 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Beijing FYF Chemicals Co., Ltd 010-57903446 15869909019 168931144@qq.com China 2876 58
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd 18210788515; 18210788515 zhuzixin999@163.c0m China 4999 55
Shanghai Brain Biotechnology Co., Ltd. 13564638271 shhjiang1977@163.com China 2983 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
Supplier Advantage
Shanghai Winherb Medical Technology Co., Ltd. 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Bide Pharmatech Ltd. 60
Beijing FYF Chemicals Co., Ltd 58
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd 55
Shanghai Brain Biotechnology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Aikon International Limited 58

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde Spectrum

4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE(6527-32-8)1HNMR

6527-32-8 (4-(Benzyloxy)-3,5-dimethoxybenzaldehyde) Related Search:

4-Benzyloxy-3-methoxybenzaldehyde 3,5-dimethoxy-4-phenylmethoxy-benzoate Methyl 4-(benzyloxy)-3,5-dimethoxybenzoate 3-(Benzyloxy)-4,5-dimethoxybenzaldehyde 3,5-Dimethoxy-4-(4-methyl-benzyloxy)-benzaldehyde
3-Methoxy-4-[(4-methoxybenzyl)oxy]benzenecarbaldehyde

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3,5-dimethoxy-4-phenylmethoxybenzaldehyde Benzaldehyde, 3,5-dimethoxy-4-(phenylmethoxy)- 6527-32-8