4-Amino-3,5-dichloropyridine N-oxide
- CAS No.
- 91872-02-5
- Chemical Name:
- 4-Amino-3,5-dichloropyridine N-oxide
- Synonyms
- Roflumilast Impurity 17;4-Amino-3,5-dichloropyridine 1-oxide;4-Amino-3,5-dichloropyridine N-oxide;3,5-dichloro-4-aminopyridine 1-oxide;4-Pyridinamine, 3,5-dichloro-, 1-oxide;4-amino-3,5-dichloropyridin-1-ium-1-olate;4-chloro-10-(cyclopropylmethoxy)-9-(difluoromethoxy)benzo[c][1,6]naphthyridin-6(5H)-one
- CBNumber:
- CB41501469
- Molecular Formula:
- C5H4Cl2N2O
- Molecular Weight:
- 179
- MDL Number:
- MOL File:
- 91872-02-5.mol
- MSDS File:
- SDS
| Melting point | 210 °C (decomp) |
|---|---|
| Boiling point | 391.6±37.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| pka | 2.25±0.10(Predicted) |
| FDA UNII | G9KH0SR06F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
4-Amino-3,5-dichloropyridine N-oxide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA006NRT | 4-Amino-3,5-dichloropyridine 1-oxide 95%+ | 91872-02-5 | 100mg | $67 | 2026-05-28 | Buy |
| aablocks | AA006NRT | 4-Amino-3,5-dichloropyridine 1-oxide 95%+ | 91872-02-5 | 250mg | $91 | 2026-05-28 | Buy |
| aablocks | AA006NRT | 4-Amino-3,5-dichloropyridine 1-oxide 95%+ | 91872-02-5 | 1g | $215 | 2026-05-28 | Buy |
| TRC | A632005 | 4-Amino-3,5-dichloropyridineN-Oxide | 91872-02-5 | 10mg | $285 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0358694 | 4-AMINO-3,5-DICHLOROPYRIDIN-1-IUM-1-OLATE 95.00% | 91872-02-5 | 5MG | $500.21 | 2021-12-16 | Buy |
4-Amino-3,5-dichloropyridine N-oxide Chemical Properties,Uses,Production
Preparation
4-amino-3,5-dichloropyridine-N-oxide is prepared by the following steps:A sealed Carius tube containing 4-nitro-3,5-dichloropyridine-N-oxide (36) (0.4 g, 1.9 mmol), aqueous ammonia (1 cm3 of 0.88 gi-l solution) and acetonitrile (1 cm3) was heated in a rotating oil bath at 70 OC for 3 h. The mixture was filtered giving a solid (0.1 g) and a filtrate, which was extracted into DCM, dried (MgS04) and evaporated giving a residue (0.0 g). The solid obtained from the filtration was recrystallised from hot methanol giving 4-amino-3,5-dichloropyridine-N-oxide (0.1 g, 30%), m.p. 210 oC from MeOH) (M+ found 177.9701. C5H4Cl2N20 requires M+ 177.9701); IR spectra no. 30; mass spectra no. 37; nmr spectrum no. 45.
Uses
4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic.
4-Amino-3,5-dichloropyridine N-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Jinan Kaixi Biotechnology Co., Ltd. | 13370511208; 15853141736 | 461667177@qq.com | China | 764 | 55 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 10000 | 58 |
| Shanghai Rlavie Technology Co., Ltd. | 021-67759270 17717059219 | sales@rlavie.com | China | 1850 | 55 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-63315541 13323832564 | 1443871971@qq.com | China | 9898 | 58 |
| Jinan Guoding Pharmaceutical Technology Co., Ltd. | 053167801621 15665775653 | sales@guodingpharma.com | China | 479 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9733 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
91872-02-5(4-Amino-3,5-dichloropyridine N-oxide)Related Search:
1of3
