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Terutroban

Terutroban Structure
Terutroban structure
CAS No.
165538-40-9
Chemical Name:
Terutroban
Synonyms
S18886;S 18886;Triplion;Terutroban;Terutroban >=95% (HPLC);Terutroban, 10 mM in DMSO;Prostaglandin Receptor,S-18886,Terutroban,inhibit,S18886,S 18886,Inhibitor;(R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid;(R)-3-(6-((4-Chlorophenyl)sulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid;(6R)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
CBNumber:
CB41508620
Molecular Formula:
C20H22ClNO4S
Molecular Weight:
407.91
MDL Number:
MFCD28411833
MOL File:
165538-40-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-23 14:48:42
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Terutroban Properties

Melting point 189 - 192°C
Boiling point 591.8±60.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 4.60±0.10(Predicted)
form Solid
color White to Off-White
optical activity [α]/D 25 to 31°, c =1 in DMSO
InChI 1S/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m0/s1
InChIKey HWEOXFSBSQIWSY-INIZCTEOSA-N
SMILES O=S(N[C@@H]1CC2=CC=C(C)C(CCC(O)=O)=C2CC1)(C3=CC=C(Cl)C=C3)=O
FDA UNII A6WX9391D8
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H319-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
target organs Respiratory system
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

Terutroban price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1198 Terutroban ≥95% (HPLC) 165538-40-9 10 mg $111 2026-04-30 Buy
Cayman Chemical 14059 S18886 ≥98% 165538-40-9 5mg $81 2026-04-30 Buy
Cayman Chemical 14059 S18886 ≥98% 165538-40-9 10mg $121 2026-04-30 Buy
Biosynth BT163710 Terutroban 165538-40-9 10mg $331.3 2026-06-04 Buy
ChemScene CS-4806 Terutroban 99.84% 165538-40-9 5mg $60 2026-06-04 Buy
Product number Packaging Price Buy
SML1198 10 mg $111 Buy
14059 5mg $81 Buy
14059 10mg $121 Buy
BT163710 10mg $331.3 Buy
CS-4806 5mg $60 Buy

Terutroban Chemical Properties, Uses, Production

Description

The lipid mediator thromboxane A2 (TXA2) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein coupled-receptor, referred to as the TXA2 receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC50 value of 16.4 nM. It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis. S18886 is the active isomer of the potent TP receptor antagonist, S18204. Antagonists of TP receptors have advantages over aspirin as they not only block the effect of TXA2 on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.

Uses

Terutroban functions as an anti-platelets therapies for patients with ischemic stroke or transient ischemic attack. Also used in the research process of anti-coagulant drugs in preventing and controlling cerebral stroke.

in vitro

s18886 was identified as the active isomer of the potent tp receptor antagonist s18204. s18886 was also found to be a selective antagonist of thromboxaneprostaglandin receptors in platelets and in the vessel wall [1].

in vivo

in a previous animal study, it was found that s18886 treatment could reduce the portal pressure in both animal models without producing significant changes in portal blood flow, indicating a reduction in hepatic vascular resistance. s18886 could not significantly change arterial pressure in ccl4 -cirrhotic rats but could significantly decrease it in bdl-cirrhotic rats [2].

IC 50

16.4 nm for tp receptor

storage

Store at -20°C

References

[1] cimetière b, dubuffet t, landras c, descombes jj, simonet s, verbeuren tj, lavielle g. new tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors. bioorg med chem lett. 1998 jun 2;8(11):1381-6.
[2] rosado e, rodríguez-vilarrupla a, gracia-sancho j, tripathi d, garcía-calderó h, bosch j, garcía-pagán jc. terutroban, a tp-receptor antagonist, reduces portal pressure in cirrhotic rats. hepatology. 2013 oct;58(4):1424-35.
[3] bousser mg, amarenco p, chamorro a, fisher m, ford i, fox km, hennerici mg, mattle hp, rothwell pm, de cordoüe a, fratacci md; perform study investigators. terutroban versus aspirin in patients with cerebral ischaemic events (perform): a randomised, double-blind, parallel-group trial. lancet. 2011 jun 11;377(9782):2013-22.

Terutroban Preparation Products And Raw materials

Raw materials

Preparation Products

Terutroban Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
LGM Pharma 70
Nanjing Norris-Pharm Technology Co., Ltd 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai Synchem Pharma Co., ltd 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Amadis Chemical Company Limited 58

View Latest Price from Terutroban manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Terutroban pictures 2026-07-22 Terutroban
165538-40-9
 $46.00-71.00 99.53% 10g TargetMol Chemicals Inc.
Terutroban pictures 2021-07-13 Terutroban
165538-40-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Terutroban pictures 2021-07-10 Terutroban
165538-40-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Terutroban pictures
  • Terutroban
    165538-40-9
  • $46.00-71.00
  • 99.53%
  • TargetMol Chemicals Inc.
  • Terutroban pictures
  • Terutroban
    165538-40-9
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Terutroban pictures
  • Terutroban
    165538-40-9
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

165538-40-9 (Terutroban) Related Search:

1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) 3-[4-(cyclopentylsulfamoyl)phenyl]propanoic acid 3-(4-Cyclopropylsulfamoyl-phenyl)-propionic acid LCB-2853 4-[[(4-Acetylphenyl)sulfonyl]amino]butanoic acid
β-Alanine, N-[(5,6,7,8-tetrahydro-2-naphthalenyl)sulfonyl]-

1of2

Terutroban S 18886 S18886 3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]PROPANOIC ACID (R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid Triplion (6R)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid 3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDROPHTHALEN-1-YL]PROPANOIC ACID 1-Naphthalenepropanoic acid, 6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-, (6R)- Terutroban >=95% (HPLC) (R)-3-(6-((4-Chlorophenyl)sulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid Prostaglandin Receptor,S-18886,Terutroban,inhibit,S18886,S 18886,Inhibitor Terutroban, 10 mM in DMSO 165538-40-9