H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
- CAS No.
- 188859-65-6
- Chemical Name:
- H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
- Synonyms
- HSLGKLLGRPDKF;L144, R147-PLP(139-151);[LEU144, ARG147]-PLP (139-151);6:PN:WO0053019 SEQID:6 claimed sequence;HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151);H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH;[Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)];L-Phenylalanine, L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-
- CBNumber:
- CB4153896
- Molecular Formula:
- C67H110N20O17
- Molecular Weight:
- 1467.72
- MDL Number:
- MFCD00792579
- MOL File:
- Mol file
H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VAC-00722 | [Leu144,Arg147]-Myelin Proteolipid Protein(139-151) | 5mg | $326.7 | 2026-06-05 | Buy | |
| Biosynth | VAC-00722 | [Leu144,Arg147]-Myelin Proteolipid Protein(139-151) | 10mg | $544.5 | 2026-06-05 | Buy | |
| Biosynth | VAC-00722 | [Leu144,Arg147]-Myelin Proteolipid Protein(139-151) | 25mg | $1089 | 2026-06-05 | Buy | |
| Biosynth | VAC-00495 | [Leu144, Arg147]-PLP (139-151), [L144, R147-PLP(139-151)] | 5mg | $326.7 | 2026-06-05 | Buy | |
| Biosynth | VAC-00495 | [Leu144, Arg147]-PLP (139-151), [L144, R147-PLP(139-151)] | 10mg | $544.5 | 2026-06-05 | Buy |
H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Chemical Properties, Uses, Production
Uses
[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1].
References
[1] Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. DOI:10.1073/pnas.94.17.9279
H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4724 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
