ChemicalBook >> CAS DataBase List >>5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER structure

CAS No.: 866028-06-0

Chemical Name:: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Synonyms: -Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4’1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine;1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate;tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat;tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018];tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate;5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester

CBNumber:: CB41559990

Molecular Formula:: C17H21FN2O3

Molecular Weight:: 320.36

MDL Number:: MFCD10566054

MOL File:: 866028-06-0.mol

MSDS File:: SDS

Last updated:2026-05-28 02:44:40

Product description	Number	Pack Size	Price
tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	303549	100.00mg	$102
tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	303549	250.00mg	$211
tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	303549	1.00g	$672
tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate >95%	B1018	100mg	$110
tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate >95%	B1018	250mg	$230

Request For Quotation

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Properties

Boiling point	473.6±45.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	12.54±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933399990

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	303549	tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	866028-06-0	100.00mg	$102	2026-05-19	Buy
Matrix Scientific	303549	tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	866028-06-0	250.00mg	$211	2026-05-19	Buy
Matrix Scientific	303549	tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate	866028-06-0	1.00g	$672	2026-05-19	Buy
Synthonix	B1018	tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate >95%	866028-06-0	100mg	$110	2026-05-06	Buy
Synthonix	B1018	tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate >95%	866028-06-0	250mg	$230	2026-05-06	Buy

Product number	Packaging	Price	Buy
303549	100.00mg	$102	Buy
303549	250.00mg	$211	Buy
303549	1.00g	$672	Buy
B1018	100mg	$110	Buy
B1018	250mg	$230	Buy

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Uses,Production

Synthesis

56341-41-4

118753-70-1

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

866028-06-0

General procedure for the synthesis of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] from 5-fluoroindol-2-one and tert-butyl N,N-bis(2-chloroethyl)carbamate: to a stirred solution of 5-fluoroindol-2-one (1.80 g, 11.9 mmol) in tetrahydrofuran (30 mL) at -78 °C A tetrahydrofuran solution (35.7 mL, 35.7 mmol) of 1 M sodium bis(trimethylmethylsilyl)amide was slowly added dropwise for 15 min. The reaction mixture was continued to be stirred at the same temperature for 1.5 hours. Subsequently, tert-butyl N,N-bis(2-chloroethyl)carbamate (2.88 g, 11.9 mmol) solution of tetrahydrofuran (10 mL) was added dropwise to the reaction mixture at -78 °C. After dropwise addition, the reaction mixture was slowly warmed to room temperature and stirred at that temperature for 19 hours. Upon completion of the reaction, the reaction was quenched by the addition of an aqueous ammonium chloride solution and the reaction mixture was subsequently concentrated to give a brown residue. The crude product was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent evaporated. The residue was purified by column chromatography on silica gel (100 g) using hexane/acetone (3/1) as eluent, resulting in 356 mg (15% yield) of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] as a light brown slurry. The product was confirmed by 1H-NMR (CDCl3) and mass spectrometry (ESI): 1H-NMR (CDCl3) δ 8.56 (1H, br.s), 7.03-6.83 (3H, m), 3.89-3.69 (4H, m), 1.92-1.72 (4H, m), 1.50 (9H, s); MS (ESI) 319 (M-H)- .

References

[1] Patent: WO2005/92858, 2005, A2. Location in patent: Page/Page column 60
[2] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 40

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

5-Fluoro-2-oxindole Tert-butyl bis(2-chloroethyl)carbamate Sodium bis(trimethylsilyl)amide Tetrahydrofuran

Preparation Products

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

Global( 41)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Qingdao Dexin Chemical Co., Ltd	+86-15553333686	15553333686@qq.com	China	3113	58
Suzhou ARTK Medchem Co., Ltd.	+8618118463618	sales1@artkmedchem.com	China	39021	58
Nanjing Moldeep Biochemical Co., Ltd.	+86-25-58282389 +8618913958656	inquiries@moldeep.com	China	19983	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10186	62
Shanghai yirong biology science and technology co., ltd	18049974220	3060526242@qq.com	China	1000	60

Supplier	Advantage
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Qingdao Dexin Chemical Co., Ltd	58
Suzhou ARTK Medchem Co., Ltd.	58
Nanjing Moldeep Biochemical Co., Ltd.	58
Amadis Chemical Company Limited	58
Pure Chemistry Scientific Inc.	62
Shanghai yirong biology science and technology co., ltd	60

View Lastest Price from 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 866028-06-0	$2.00	1g	98%min		Career Henan Chemical Co

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
866028-06-0
$2.00
98%min
Career Henan Chemical Co

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Spectrum

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(866028-06-0)¹HNMR

866028-06-0(5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER)Related Search:

1-N-BOC-4-AMINOMETHYL-4-PHENYLPIPERIDINE [2-(2,3-DIHYDRO-1H-INDOL-3-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER SPIRO[INDOLINE-3,4'-PIPERIDINE] PIPERIDINE-4-CARBOXYLIC ACID (4-FLUORO-PHENYL)-AMIDE

4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE 1'-N-BOC-1,2-DIHYDRO-1'H-SPIRO[INDOLE-3,4'-PIPERIDINE] 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

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1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester -Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4&rsquo 1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018] 866028-06-0 C17H21FN2O3