4-(4-Fluorophenyl)butanoic acid
- CAS No.
- 589-06-0
- Chemical Name:
- 4-(4-Fluorophenyl)butanoic acid
- Synonyms
- CHEMBRDG-BB 4002813;TIMTEC-BB SBB010216;4-Fluorobenzenebutanoic acid;4-(p-fluorophenyl)butyric acid;4-(4-FLUOROPHENYL)BUTYRIC ACID;-(4-Fluorophenyl)butanoic acid;Benzenebutanoic acid, 4-fluoro-;4-(4-Fluorophenyl)butanoic acid
- CBNumber:
- CB4168566
- Molecular Formula:
- C10H11FO2
- Molecular Weight:
- 182.19
- MDL Number:
- MFCD03788503
- MOL File:
- 589-06-0.mol
- MSDS File:
- SDS
| Melting point | 45 °C |
|---|---|
| Boiling point | 161-164 °C(Press: 4 Torr) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.75±0.10(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 589-06-0(CAS DataBase Reference) |
| FDA UNII | FH9535EGU6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | C,Xi,Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
4-(4-Fluorophenyl)butanoic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 61020 | 4-(4-FLUORO-PHENYL)-BUTYRIC ACID 97% | 589-06-0 | 1G | $43 | 2026-04-30 | Buy |
| AstaTech | 61020 | 4-(4-FLUORO-PHENYL)-BUTYRIC ACID 97% | 589-06-0 | 5G | $133 | 2026-04-30 | Buy |
| AstaTech | 61020 | 4-(4-FLUORO-PHENYL)-BUTYRIC ACID 97% | 589-06-0 | 10G | $200 | 2026-04-30 | Buy |
| Biosynth | FF105063 | 4-(4-fluorophenyl)butanoic Acid | 589-06-0 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FF105063 | 4-(4-fluorophenyl)butanoic Acid | 589-06-0 | 2g | $900 | 2026-06-04 | Buy |
4-(4-Fluorophenyl)butanoic acid Chemical Properties, Uses, Production
Synthesis
366-77-8
589-06-0
Synthesis of 4-(4-fluorophenyl)butyric acid: 4-(4-fluorophenyl)-4-oxobutanoic acid (0.98 g, 5 mmol) and 85% KOH (0.79 g, 12 mmol) were added to a round bottomed flask fitted with a Dean-Stark apparatus and a reflux condenser and suspended in diethylene glycol (10 mL). 50% hydrazine monohydrate (1.20 g, 12 mmol) was added slowly at room temperature and the reaction mixture was subsequently heated to 120-130 °C and maintained for 2 hours. After about 45 min, the reaction mixture became homogeneous. after 2 h, the temperature was increased to 180-200 °C and stirring was continued for 3 h. Residual hydrazine and water were removed by means of a Dean-Stark water separator. After completion of the reaction, it was cooled to room temperature, diluted with H2O (10 mL) and poured into 2.5N aqueous HCl (20 mL). The organic product was extracted with EtOAc (3 x 15 mL), the organic phases were combined, washed with brine (10 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification by column chromatography (30-50% EtOAc/hexane) afforded the target product 4-(4-fluorophenyl)butanoic acid as a clear viscous oil (0.32 g, 35%).1H NMR (500 MHz, CDCl3): δ 11.50 (br, 1H), 7.16 (m, 2H), 7.00 (m, 2H), 2.67 (t, J = 7.6 Hz, 2H), 2.40 (t, J = 7.4 Hz, 2H), 1.97 (quin, J = 7.5 Hz, 2H).13C NMR (125 MHz, CDCl3): δ 180.16, 161.34 (d, J = 243.4 Hz), 136.74, 129.76 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz) 115.09 (d, J = 20.9 Hz), 34.09, 33.20, 26.24.
References
[1] Patent: US5872118, 1999, A
[2] Patent: US6124284, 2000, A
[3] Patent: US5719186, 1998, A
[4] Archiv der Pharmazie, 1998, vol. 331, # 12, p. 395 - 404
[5] Patent: WO2015/134973, 2015, A1. Location in patent: Page/Page column 98
4-(4-Fluorophenyl)butanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Baiyin Chengze Chemical Technology Co., Ltd. | +86 943-8535351 13389336721 | sales@chengzechem.com | China | 300 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
View Latest Price from 4-(4-Fluorophenyl)butanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | 4-(4-Fluorophenyl)butanoic acid
589-06-0
|
$2.00 | 1KG | 98%min | Career Henan Chemical Co |
-
- 4-(4-Fluorophenyl)butanoic acid
589-06-0
- $2.00
- 98%min
- Career Henan Chemical Co
589-06-0 (4-(4-Fluorophenyl)butanoic acid) Related Search:
1of4
