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4-[2-(Dimethylamino)ethoxy]benzaldehyde

4-[2-(Dimethylamino)ethoxy]benzaldehyde Structure
4-[2-(Dimethylamino)ethoxy]benzaldehyde structure
CAS No.
15182-92-0
Chemical Name:
4-[2-(Dimethylamino)ethoxy]benzaldehyde
Synonyms
AKOS BC-2175;CHEMBRDG-BB 4003884;TIMTEC-BB SBB010890;p-[2-(dimethylamino)ethoxy]benzaldehyde;4-[2-(Dimethylamino)ethoxy]benzaldehyde;Benzaldehyde, 4-[2-(diMethylaMino)ethoxy]-;4-[2-(Dimethylamino)ethoxy]benzaldehyde 95%;4-[2-(dimethylamino)ethoxy]benzaldehyde(SALTDATA: FREE);1-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]quinazoline-2,4-dione
CBNumber:
CB4170497
Molecular Formula:
C11H15NO2
Molecular Weight:
193.24
MDL Number:
MFCD07368978
MOL File:
15182-92-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:29
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4-[2-(Dimethylamino)ethoxy]benzaldehyde Properties

Boiling point 142 °C
Density 1.062±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Sparingly), DMSO (Sparingly)
pka 8.55±0.28(Predicted)
form Oil
color Brown to Dark Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H227
Precautionary statements  P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
Hazard Codes  C,Xi
Hazard Note  Corrosive
HazardClass  IRRITANT
HS Code  2912490090
NFPA 704
1
3 0

4-[2-(Dimethylamino)ethoxy]benzaldehyde price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-B400228-500MG 4-[2-(Dimethylamino)ethoxy]benzaldehyde 15182-92-0 500mg $101 2026-06-03 Buy
TRC TRC-B400228-250MG 4-[2-(Dimethylamino)ethoxy]benzaldehyde 15182-92-0 250mg $70 2026-06-03 Buy
TRC TRC-B400228-100MG 4-[2-(Dimethylamino)ethoxy]benzaldehyde 15182-92-0 100mg $60 2026-06-03 Buy
Apolloscientific OR9649 4-[2-(Dimethylamino)ethoxy]benzaldehyde 97% 15182-92-0 250mg $25 2026-06-04 Buy
Apolloscientific OR9649 4-[2-(Dimethylamino)ethoxy]benzaldehyde 97% 15182-92-0 1g $86 2026-06-04 Buy
Product number Packaging Price Buy
TRC-B400228-500MG 500mg $101 Buy
TRC-B400228-250MG 250mg $70 Buy
TRC-B400228-100MG 100mg $60 Buy
OR9649 250mg $25 Buy
OR9649 1g $86 Buy

4-[2-(Dimethylamino)ethoxy]benzaldehyde Chemical Properties, Uses, Production

Uses

4-[2-(Dimethylamino)ethoxy]benzaldehyde is used in preparation of cyclosporin A analogs as NTCP inhibitors.

Synthesis

2-Dimethylaminoethyl chloride hydrochloride

4584-46-7

4-Hydroxybenzaldehyde

123-08-0

4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE

15182-92-0

First, 80 g of p-hydroxybenzaldehyde, 128 g of potassium carbonate, 150 mL of DMF and 10 mL of isopropyl were mixed and stirred. Subsequently, 101 g of 2-(dimethylamino)chloroethane hydrochloride was added to the mixture, followed by 80 g of triethylamine. The reaction mixture was stirred at 80°C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, poured into 700 mL of water and extracted with 500 mL of chloroform. 300 mL of 2 mol-L-1 sulfuric acid was added to the chloroform layer for extraction. To the aqueous phase, 200 mL of 20% sodium hydroxide solution was added under ice water bath conditions, followed by extraction with 1000 mL of ethyl acetate. The organic phase was dried with anhydrous sodium sulfate and the ethyl acetate was recovered under reduced pressure. The fractions with boiling points of 142-144 °C/0.533 kPa were collected by distillation under reduced pressure to give 110.2 g of 4-(2-dimethylaminoethoxy)benzaldehyde in 86.3% yield. 100 g of 4-(2-dimethylaminoethoxy)benzaldehyde was dissolved in 150 mL of methanol and 26.5 g of sodium borohydride was slowly added under ice bath conditions, and the progress of the reaction was monitored by TLC until the reaction was complete. Excess sodium borohydride was quenched by addition of ammonium chloride. After removing methanol under reduced pressure, 300 mL of water was added to the crude product and extracted with 200 mL of ethyl acetate. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by distillation under reduced pressure to give 87.9 g of colorless liquid in 87% yield.

References

[1] Patent: CN106518706, 2017, A. Location in patent: Paragraph 0009
[2] Patent: WO2006/51079, 2006, A1. Location in patent: Page/Page column 5
[3] Patent: WO2015/91531, 2015, A1. Location in patent: Page/Page column 52
[4] Patent: WO2015/86693, 2015, A1. Location in patent: Page/Page column 65
[5] Patent: WO2012/79154, 2012, A1. Location in patent: Page/Page column 76; 77

4-[2-(Dimethylamino)ethoxy]benzaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Sodium sulfate Potassium carbonate 2-Dimethylaminoethyl chloride hydrochloride 4-Hydroxybenzaldehyde
Diethyl ether Toluene-4-sulfonic acid 2-(4-formyl-phenoxy)-ethyl ester Methanesulfonic acid, 2-(dimethylamino)ethyl ester Dimethylamine hydrochloride 2-Chloroethyldimethylamine

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Preparation Products

4-[2-(Dimethylamino)ethoxy]benzaldehyde Suppliers

Global Suppliers ( 89)
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 025-58196018 800028039 sales@fartop.net China 2227 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Nanjing River Chemical Co., Ltd. 13951936332 18305166317 info@serpharm.com China 493 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
Capot Chemical Co., Ltd 66
Adamas Reagent, Ltd. 59
Thermo Fisher Scientific 75
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 55
9ding chemical ( Shanghai) Limited 55
Bide Pharmatech Ltd. 60
Shanghai Kewel Chemical Co., Ltd. 50
Shanghai HuanChuan Industry Co.,Ltd. 50
Nanjing River Chemical Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from 4-[2-(Dimethylamino)ethoxy]benzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE pictures 2020-02-21 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE
15182-92-0
 $3.00 1KG 98% 200KG Career Henan Chemical Co

4-[2-(Dimethylamino)ethoxy]benzaldehyde Spectrum

4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE(15182-92-0)1HNMR

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CHEMBRDG-BB 4003884 AKOS BC-2175 TIMTEC-BB SBB010890 p-[2-(dimethylamino)ethoxy]benzaldehyde 4-[2-(Dimethylamino)ethoxy]benzaldehyde 95% 4-[2-(dimethylamino)ethoxy]benzaldehyde(SALTDATA: FREE) Benzaldehyde, 4-[2-(diMethylaMino)ethoxy]- 1-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]quinazoline-2,4-dione 4-[2-(Dimethylamino)ethoxy]benzaldehyde 15182-92-0