morclofone
- CAS No.
- 31848-01-8
- Chemical Name:
- morclofone
- Synonyms
- morclofone;4'-Chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone;4'-chloro-3,5-dimethoxy-4-(2-morpholin-4-yl-ethoxy)-benzophenone;Methanone, (4-chlorophenyl)[3,5-dimethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]-
- CBNumber:
- CB0884918
- Molecular Formula:
- C21H24ClNO5
- Molecular Weight:
- 405.87
- MDL Number:
- MOL File:
- 31848-01-8.mol
| Melting point | 91-92° |
|---|---|
| Boiling point | 563.1±50.0 °C(Predicted) |
| Density | 1.220±0.06 g/cm3(Predicted) |
| pka | 6.28±0.10(Predicted) |
| FDA UNII | VY62TIB872 |
| ATC code | R05DB25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H332-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 |
| Toxicity | LD50 orally in mice: 552 mg/kg (Lauria) |
morclofone Chemical Properties, Uses, Production
Originator
Plausitin,Carlo Erba,Italy,1975
Definition
ChEBI: Morclofone is a member of benzophenones.
Manufacturing Process
Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with 3,5-dimethoxy-4'-chloro-4-hydroxybenzophenone (6 g) in dimethylformamide (50 ml), for 2 hours at 120°C. The reaction mixture was then treated with β- morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140C, then evaporated to dryness, and treated with water to give a solid material. The mixture was filtered, washed and crystallized from cyclohexane to give 3,5- dimethoxy-4'-chloro-4-(β-morpholinoethoxy)-benzophenone (6.5 g), MP 91°C to 92°C. The product was then reacted at about 0°C with gaseous hydrogen chloride in ether to give, after crystallization from isopropanol, the corresponding hydrochloride which had a MP of 187.9°C.
Therapeutic Function
Antitussive
morclofone Preparation Products And Raw materials
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