6-chloroquinoline-8-carboxylic acid
- CAS No.
- 6456-78-6
- Chemical Name:
- 6-chloroquinoline-8-carboxylic acid
- Synonyms
- 3-BROMO-24-CHLOROPHENOL;6-Chloroquinoline-8-CarboxylicAci;6-chloroquiolie-8-carboxylic acid;6-Chloro-8-quinolinecarboxylic Acid;6-chloroquinoline-8-carboxylic acid;8-Quinolinecarboxylic acid, 6-chloro-;6-chloroquinoline-8-carboxylic acid ISO 9001：2015 REACH
- CBNumber:
- CB41785090
- Molecular Formula:
- C10H6ClNO2
- Molecular Weight:
- 207.61
- MDL Number:
- MFCD02752433
- MOL File:
- 6456-78-6.mol
- MSDS File:
- SDS
| Melting point | 220-222°C |
|---|---|
| Boiling point | 143 °C(Press: 12 Torr) |
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetonitrile (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | -2.78±0.10(Predicted) |
| color | Brown |
| FDA UNII | 9PP5MQZ3Z5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H335-H319-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
6-chloroquinoline-8-carboxylic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C379910-50MG | 6-Chloro-8-quinolinecarboxylic Acid | 6456-78-6 | 50mg | $103 | 2026-06-03 | Buy |
| TRC | TRC-C379910-250MG | 6-Chloro-8-quinolinecarboxylic Acid | 6456-78-6 | 250mg | $358 | 2026-06-03 | Buy |
| TRC | TRC-C379910-100MG | 6-Chloro-8-quinolinecarboxylic Acid | 6456-78-6 | 100mg | $161 | 2026-06-03 | Buy |
| Matrix Scientific | 073663 | 6-Chloroquinoline-8-carboxylic acid | 6456-78-6 | 1.00g | $347 | 2026-05-18 | Buy |
| Matrix Scientific | 073663 | 6-Chloroquinoline-8-carboxylic acid | 6456-78-6 | 5.00g | $899 | 2026-05-18 | Buy |
6-chloroquinoline-8-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
Brown Solid
Uses
A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent.
Synthesis
56-81-5
635-21-2
6456-78-6
General procedure for the synthesis of 6-chloroquinoline-8-carboxylic acid from glycerol and 2-amino-5-chlorobenzoic acid: 1.01 g of 2-amino-5-chlorobenzoic acid, 26.6 mg of iodine, and 0.76 g of glycerol were mixed, and the mixture was vigorously stirred. 0.44 mL of concentrated sulfuric acid was slowly added dropwise at 65 °C to 70 °C and the reaction was carried out for 30 minutes. Subsequently, the reaction temperature was raised to 140 °C and the reaction was continued for 6 hours. Upon completion of the reaction, 17 mL of water at 0 °C was added, the pH was adjusted to 6.5, the solid was collected by filtration and washed with cold water, and then dried. The dried residue was dissolved in chloroform and filtered to remove insoluble material. Activated carbon was added to the filtrate to adsorb impurities and the activated carbon was removed by filtration again. The solvent was removed by distillation and the resulting residue was recrystallized in a mixed solution of chloroform and ethyl acetate. The resulting crystals were washed with ethyl acetate and the solvent was again removed by distillation, resulting in 96.2 mg (7.9% yield) of the target product 6-chloroquinoline-8-carboxylic acid. The compound was subjected to NMR, mass spectrometry and melting point determination, confirming that its structure conforms to the general formula of 6-chloroquinoline-8-carboxylic acid.
References
[1] Patent: WO2008/59513, 2008, A2. Location in patent: Page/Page column 14
[2] Patent: US2009/171091, 2009, A1. Location in patent: Page/Page column 6
[3] Patent: JP2018/52866, 2018, A. Location in patent: Paragraph 0046
6-chloroquinoline-8-carboxylic acid Preparation Products And Raw materials
6-chloroquinoline-8-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Runpharm Technology Limited | 18171398856 2968382473 | service@runpharm.com | China | 716 | 55 |
View Latest Price from 6-chloroquinoline-8-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-chloroquinoline-8-carboxylic acid
6456-78-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-20 | 6-chloroquinoline-8-carboxylic acid
6456-78-6
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 6-chloroquinoline-8-carboxylic acid
6456-78-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-chloroquinoline-8-carboxylic acid
6456-78-6
- $1.00
- 99%
- Career Henan Chemical Co
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