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2-Amino-5-chlorobenzoic acid

2-Amino-5-chlorobenzoic acid structure

CAS No.: 635-21-2

Chemical Name:: 2-Amino-5-chlorobenzoic acid

Synonyms: 5-CHLOROANTHRANILIC ACID;2-CARBOXY-4-CHLOROANILINE;NSC 404157;2-Amino-5-chL;RARECHEM AL BO 0288;5-Chloranthranilsure;OTAVA-BB BB7020040772;5-Chloro-2-amino acid;Anthranilic acid, 5-chloro-;2-amino-5-chloro-benzoicaci

CBNumber:: CB0107619

Molecular Formula:: C7H6ClNO2

Molecular Weight:: 171.58

MDL Number:: MFCD00007838

MOL File:: 635-21-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:22:23

Product description	Number	Pack Size	Price
2-Amino-5-chlorobenzoic acid 90%, technical grade	378046	25g	$82.4
2-Amino-5-chlorobenzoic acid 98%	A45475	10g	$185
5-Chloroanthranilic Acid >99.0%(T)	A0665	5g	$23
5-Chloroanthranilic Acid >99.0%(T)	A0665	25g	$55
2-Amino-5-chlorobenzoic acid Asreported	258131	5g	$270
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2-Amino-5-chlorobenzoic acid Properties

Melting point	204-206 °C (dec.) (lit.)
Boiling point	250°C (rough estimate)
Density	1.3246 (rough estimate)
refractive index	1.5560 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.57±0.10(Predicted)
color	White to Pale Grey
Water Solubility	Soluble in water.
BRN	639027
Major Application	peptide synthesis
InChI	1S/C7H6ClNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey	IFXKXCLVKQVVDI-UHFFFAOYSA-N
SMILES	Nc1ccc(Cl)cc1C(O)=O
CAS DataBase Reference	635-21-2(CAS DataBase Reference)
FDA UNII	Z2Y66JMI31
NIST Chemistry Reference	Benzoic acid, 2-amino-5-chloro-(635-21-2)
EPA Substance Registry System	Benzoic acid, 2-amino-5-chloro- (635-21-2)
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-37/38-36

Safety Statements

26-36-37/39

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29224999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Amino-5-chlorobenzoic acid price More Price(111)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	378046	2-Amino-5-chlorobenzoic acid 90%, technical grade	635-21-2	25g	$82.4	2026-04-30	Buy
Sigma-Aldrich	A45475	2-Amino-5-chlorobenzoic acid 98%	635-21-2	10g	$185	2023-06-20	Buy
TCI Chemical	A0665	5-Chloroanthranilic Acid >99.0%(T)	635-21-2	5g	$23	2026-04-30	Buy
TCI Chemical	A0665	5-Chloroanthranilic Acid >99.0%(T)	635-21-2	25g	$55	2026-04-30	Buy
Usbiological	258131	2-Amino-5-chlorobenzoic acid Asreported	635-21-2	5g	$270	2026-06-03	Buy

Product number	Packaging	Price	Buy
378046	25g	$82.4	Buy
A45475	10g	$185	Buy
A0665	5g	$23	Buy
A0665	25g	$55	Buy
258131	5g	$270	Buy

2-Amino-5-chlorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powder

Uses

2-Amino-5-chlorobenzoic acid is a chlorinated derivative of antharilic acid,it is a metabolite of the pesticide Chlordimeform and it is used in the preparation of disease-modifying antirheumatic drugs (DMARDs).

Uses

5-Chloroanthranilic Acid is a chlorinated derivative of anthranilic acid. 5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. 5-Chloroanthranilic Acid is used in the preparation o f disease-modifying antirheumatic drugs (DMARDs).

Uses

2-Amino-5-chlorobenzoic acid is used in the preparation of disease-modifying antirheumatic drugs (DMARDs). Also used to produce 6-chloro-3H-quinazolin-4-one at temperature of 180°C.

Definition

ChEBI: 2-amino-5-chlorobenzoic acid is a member of the class of chlorobenzoic acids that is benzoic acid in which the ring hydrogens at positions 2 and 5 are replaced by amino and chloro groups, respectively. It is an aminobenzoic acid, a member of monochlorobenzenes and a chlorobenzoic acid.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2516-95-2

635-21-2

General procedure for the synthesis of 2-amino-5-chlorobenzoic acid from 5-chloro-2-nitrobenzoic acid: active Raney nickel (2 g) was added to the reaction flask, followed by the addition of an ethanol solution of 5-chloro-2-nitrobenzoic acid (20 g, 110 mmol). The reaction mixture was stirred at room temperature in a hydrogen atmosphere overnight. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 16 g of white solid product (96% yield). The product was characterized by 1H NMR (DMSO-d6): δ 6.77 (d, J = 8.9 Hz, 1H), 7.24 (dd, J = 2.9, 8.9 Hz, 1H), 7.62 (d, J = 2.9 Hz, 1H), 8.7 (br, 3H); EIMS: 170 (M-H).

References

[1] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[2] Patent: WO2004/74218, 2004, A2. Location in patent: Page 115-116
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 12, p. 2801 - 2809
[4] Chemical Biology and Drug Design, 2016, p. 710 - 723
[5] Zhurnal Obshchei Khimii, 1938, vol. 8, p. 1797,1801

2-Amino-5-chlorobenzoic acid synthesis

Synthesis of 2-Amino-5-chlorobenzoic acid from 5-Chloro-2-nitrobenzoic acid

2-Amino-5-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

1-(4-Chlorophenyl)-2-phenyldiazene 2-Azido-5-chlorobenzoic acid 4-CHLORO-2-METHYLACETANILIDE 2-Bromo-5-chlorobenzoic acid Anthranilic acid

5-Chloroindole Methyl 5-chloroanthranilate 5-Chloroisatin 3,5-Dichloroanthranilic acid 5-Chloro-2-nitrobenzoic acid

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Preparation Products

3-Chlorobenzoic acid 5-Chloro-2-fluorobenzoic acid (2-AMINO-5-CHLOROBENZOYL)HYDRAZIDE Ethanone,1-(2-amino-5-chlorophenyl)- 2-Amino-5-chlorobenzaldehyde

2-amino-N-butyl-5-chlorobenzamide

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2-Amino-5-chlorobenzoic acid Suppliers

Global( 491)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5220	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-18712993135	sales01@tairunfaz.com	China	8051	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Fengjia New Material Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 2-Amino-5-chlorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	2-Amino-5-chlorobenzoic acid 635-21-2	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-11	2-Amino-5-chlorobenzoic acid 635-21-2	$38.00-98.00		99.51%	10g	TargetMol Chemicals Inc.
2026-05-09	2-Amino-5-chlorobenzoic acid 635-21-2	$38.00-98.00		99.51%	10g	TargetMol Chemicals Inc.

2-Amino-5-chlorobenzoic acid
635-21-2
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

2-Amino-5-chlorobenzoic acid
635-21-2
$38.00-98.00
99.51%
TargetMol Chemicals Inc.

2-Amino-5-chlorobenzoic acid
635-21-2
$38.00-98.00
99.51%
TargetMol Chemicals Inc.

2-Amino-5-chlorobenzoic acid Spectrum

2-Amino-5-chlorobenzoic acid(635-21-2)MS 2-Amino-5-chlorobenzoic acid(635-21-2)¹HNMR 2-Amino-5-chlorobenzoic acid(635-21-2)IR1 2-Amino-5-chlorobenzoic acid(635-21-2)IR2 2-Amino-5-chlorobenzoic acid(635-21-2)Raman

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2-AMINO-5-CHLOROBENZOIC ACID 2-CARBOXY-4-CHLOROANILINE 5-AMINO-3-CARBOXY-1-CHLOROBENZENE 5-CHLORO-2-AMINOBENZOIC ACID OTAVA-BB BB7020040772 RARECHEM AL BO 0288 2-amino-5-chloro-benzoicaci Anthranilic acid, 5-chloro- 2-AMINO-5-CHLOROBENZOIC ACID, TECH., 90% Benzoic acid, 2-amino-5-chloro- 2-Amino-5-chL 5-Chloro-2-amino acid 2-Amino-5-Chlorbenzoic Acid 2-Amino-5-chlorobenzoic acid,98% NSC 404157 5-Chloroanthranilic acid, 2-Carboxy-4-chloroaniline 5-CHLORO-2-AMINEBENOATIC ACID 2-AMINO-5-CHLOROBENZOIC ACID (5-CHLOROANTHRANILIC ACID) 5-Chloroanthranilic Acid > 2-Amino-5-chlorobenzoic acid USP/EP/BP Chemical Reagent Bloom Tech 2-Amino-5-Chlorobenzoic Acid CAS 635-21-2 5-Chloranthranilsure 2-Amino-5-chlorobbenic acid 2-Amino-5-chlorobenzoic acid [ACBA] 2-Amino-5-chlorobenzoic acid, 10 mM in DMSO 5-CHLOROANTHRANILIC ACID 635-21-2 Peptide Synthesis Unnatural Amino Acid Derivatives Specialty Synthesis Aromatic Amino Acids Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Organic acids Acids & Esters Anilines, Amides & Amines Chlorine Compounds amine| carboxylic acid| alkyl chloride Aromatics, Intermediates, Metabolites & Impurities API Intermediate Amino Acids and Derivatives Aromatics Intermediates Metabolites & Impurities FINE Chemical & INTERMEDIATES