1,3-Benzodioxole
- CAS No.
- 274-09-9
- Chemical Name:
- 1,3-Benzodioxole
- Synonyms
- Benzo[d][1,3]dioxole;Benzodioxole;1,2-METHYLENEDIOXYBENZENE;MDB;1,3-BENZODIOXOL;1,2-METHYLENDIOXYBENZENE;1,2-Methylenedioxybenzene (MDB);1,3-Dioxindan;1,3-DIOXAINDANE;BENZO[1,3]DIOXOLE
- CBNumber:
- CB4180652
- Molecular Formula:
- C7H6O2
- Molecular Weight:
- 122.12
- MDL Number:
- MFCD00005818
- MOL File:
- 274-09-9.mol
- MSDS File:
- SDS
| Melting point | -18 °C |
|---|---|
| Boiling point | 172-173 °C(lit.) |
| Density | 1.064 g/mL at 25 °C(lit.) |
| vapor pressure | 12 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 131 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 2g/l |
| form | Powder |
| color | Yellow to orange to brown |
| Water Solubility | 0.2 g/100 mL (25 ºC) |
| BRN | 115506 |
| InChI | 1S/C7H6O2/c1-2-4-7-6(3-1)8-5-9-7/h1-4H,5H2 |
| InChIKey | FTNJQNQLEGKTGD-UHFFFAOYSA-N |
| SMILES | C1Oc2ccccc2O1 |
| LogP | 2.08 |
| CAS DataBase Reference | 274-09-9(CAS DataBase Reference) |
| FDA UNII | F0XLL582B8 |
| NIST Chemistry Reference | 1,3-Benzodioxole(274-09-9) |
| EPA Substance Registry System | 1,3-Benzodioxole (274-09-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/22-22-10-36/37/38-20/21/22-10/22 | |||||||||
| Safety Statements | 23-24/25-36/37/39-26-16-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DA5600000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29329970 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1,3-Benzodioxole price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159166 | 1,3-Benzodioxole 99% | 274-09-9 | 50g | $70.2 | 2026-04-30 | Buy |
| TCI Chemical | M0658 | 1,2-Methylenedioxybenzene >99.0%(GC) | 274-09-9 | 25mL | $25 | 2026-04-30 | Buy |
| TCI Chemical | M0658 | 1,2-Methylenedioxybenzene >99.0%(GC) | 274-09-9 | 100mL | $64 | 2026-04-30 | Buy |
| Usbiological | 261603 | 1,3-Benzodioxole Asreported | 274-09-9 | 25g | $340 | 2026-06-03 | Buy |
| Usbiological | 261603 | 1,3-Benzodioxole Asreported | 274-09-9 | 50g | $468 | 2026-06-03 | Buy |
1,3-Benzodioxole Chemical Properties,Uses,Production
Description
1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.
Chemical Properties
clear colourless to light yellow liquid. Insoluble in acids.
Uses
1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.
Definition
ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.
Production Methods
1,3-Benzodioxole is synthesized through the reaction of catechol with dihalomethanes, typically employing a concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.
Application
1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.
General Description
Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.
1,3-Benzodioxole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Lenny Technology Co. , Ltd. | 571-88086013 | sunnie@rdpharm.com | China | 105 | 60 |
| Shanghai Xianggeng Technology Development Co. Ltd. | 021-021-56152668 18116302010 | sharing@sharingtechcn.com | China | 499 | 58 |
| Nanjing Dilu Pharmaceutical Co., Ltd | 18014482516 18014482516 | 977144864@qq.com | China | 424 | 58 |
| Shanghai Kuncheng Industrial Co., LTD | 15317029879 15317029879 | shkcsy@yeah.net | China | 12 | 58 |
| Shandong YingLang Chemical Co.,Ltd | 18266343295 | chen@chemwww.com | China | 4829 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
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View Lastest Price from 1,3-Benzodioxole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | 1,3-Benzodioxole
274-09-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | 1,3-Benzodioxole
274-09-9
|
$5.00 | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-02 | 1,3-Benzodioxole
274-09-9
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 1,3-Benzodioxole
274-09-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1,3-Benzodioxole
274-09-9
- $5.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 1,3-Benzodioxole
274-09-9
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
