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3,4-(METHYLENEDIOXY)BUTYROPHENONE

3,4-(METHYLENEDIOXY)BUTYROPHENONE structure

CAS No.: 63740-97-6

Chemical Name:: 3,4-(METHYLENEDIOXY)BUTYROPHENONE

Synonyms: 3'-Chlorobutanophenone;1-(1,3-Benzodioxol-5-yl)-;5-Butyryl-1,3-benzodioxole;1,3-BENZODIOXOLE-5-BUTYROYL;3,4-METHYLENEDIOXYPHENYL-BUTONE;3,4-(METHYLENEDIOXY)BUTYROPHENONE;1-(1,3-Benzodioxol-5-yl)-1-butanone;1-(1,3-benzodioxol-5-yl)butan-1-one;1-(Benzod1,3dioxol-5-yl)-1-butanone;3',4'-(Methylenedioxy)butyrophenone

CBNumber:: CB2482644

Molecular Formula:: C11H12O3

Molecular Weight:: 192.21

MDL Number:: MFCD01075043

MOL File:: 63740-97-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:53

Product description	Number	Pack Size	Price
1-(1,3-Benzodioxol-5-yl)-1-butanone	176341	1.00g	$316
1-(1,3-Benzodioxol-5-yl)-1-butanone	176341	5.00g	$810
1-(1,3-Benzodioxol-5-yl)-1-butanone	176341	10.00g	$1170
1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one 98%	B54575	1g	$60
1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one 98%	B54575	10g	$60
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3,4-(METHYLENEDIOXY)BUTYROPHENONE Properties

Melting point	47-49°C
Boiling point	319.3±31.0 °C(Predicted)
Density	1.163±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
BRN	168758
CAS DataBase Reference	63740-97-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
HS Code	29329990

3,4-(METHYLENEDIOXY)BUTYROPHENONE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	176341	1-(1,3-Benzodioxol-5-yl)-1-butanone	63740-97-6	1.00g	$316	2026-05-18	Buy
Matrix Scientific	176341	1-(1,3-Benzodioxol-5-yl)-1-butanone	63740-97-6	5.00g	$810	2026-05-18	Buy
Matrix Scientific	176341	1-(1,3-Benzodioxol-5-yl)-1-butanone	63740-97-6	10.00g	$1170	2026-05-18	Buy
Synthonix	B54575	1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one 98%	63740-97-6	1g	$60	2026-05-06	Buy
Synthonix	B54575	1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one 98%	63740-97-6	10g	$60	2026-05-06	Buy

Product number	Packaging	Price	Buy
176341	1.00g	$316	Buy
176341	5.00g	$810	Buy
176341	10.00g	$1170	Buy
B54575	1g	$60	Buy
B54575	10g	$60	Buy

3,4-(METHYLENEDIOXY)BUTYROPHENONE Chemical Properties,Uses,Production

Chemical Properties

3,4-(METHYLENEDIOXY)BUTYROPHENONE is White to cream solid

Uses

Used in the synthesis of α-propylpiperonylamine and analogs.

Uses

3,4-(METHYLENEDIOXY)BUTYROPHENONE is used in the synthesis of α-propylpiperonylamine and analogs.

Synthesis

106-31-0

274-09-9

63740-97-6

To a pre-dried two-necked round-bottomed flask were added 1,2-methylenedioxybenzene (piperylene ring, 2.0 g, 16.37 mmol), 1,2-dichloroethane (7 mL) and n-butyric anhydride (3.2 mL, 19.6 mmol). The reaction mixture was cooled to -10 °C and boron trifluoride ethyl ether complex (BF3-Et2O, 6.78 g, 47.7 mmol) was slowly added dropwise over 15 min while keeping the reaction temperature between -5 °C and 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at -5 °C for 3 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium acetate solution, and the organic layer was separated and washed sequentially with 5% aqueous sodium hydroxide solution (7 mL) and deionized water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate (10:1, v/v) as eluent to afford the target compound 3,4-(methylenedioxy)phenylbutanone (1.34 g, 85% yield). 1H NMR (400 MHz, CDCl3) δ: 7.52 (dd, J = 8.1, 1.6 Hz, 1H), 7.40 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 8.1 Hz, 1H), 5.99 (s, 1H), 2.82 (t, J = 7.3 Hz, 2H), 1.70 (h, J = 7.4 Hz, 2H ), 0.95 (t, J = 7.4 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ: 198.4, 151.5, 148.1, 132.0, 124.1, 107.8, 107.7, 101.7, 40.2, 18.0, 13.8. HRMS-ESI-MS (m/z) [M + H]+: calculated value C11H13O3: 193.0865; measured value: 193.0867.

References

[1] Organic Process Research and Development, 2002, vol. 6, # 1, p. 54 - 63
[2] Tetrahedron, 2013, vol. 69, # 1, p. 268 - 273
[3] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 13, p. 2668 - 2674

3,4-(METHYLENEDIOXY)BUTYROPHENONE synthesis

Synthesis of 3,4-(METHYLENEDIOXY)BUTYROPHENONE from 1,3-Benzodioxole and Butyryl chloride

3,4-(METHYLENEDIOXY)BUTYROPHENONE Preparation Products And Raw materials

Raw materials

1-(1,3-benzodioxol-5-yl)butan-1-ol 1,3-Benzodioxole Butyric anhydride Formic acid 1-IODO-3,4-METHYLENEDIOXYBENZENE

2-BROMOPROPENE 1-Bromopropane Butyryl chloride 1,2-Dichloroethane Piperonyl aldehyde

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Preparation Products

1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutan-1-one 2-Bromo-3',4'-(methylenedioxy)propiophenone

3,4-(METHYLENEDIOXY)BUTYROPHENONE Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
henan kanbei chemical co.,ltd	+undefined-86-1523780-4566 +undefined15237804566	henankanbeichemical@163.com	China	511	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9953	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
CR Corporation Limited	58
CD Chemical Group Limited	58
Hebei Chuanghai Biotechnology Co., Ltd	58
henan kanbei chemical co.,ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from 3,4-(METHYLENEDIOXY)BUTYROPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6	US $40.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.
2022-09-27	3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6	US $0.00 / kg	1kg	99%	1000kg	henan kanbei chemical co.,ltd
2021-07-02	3,4-(METHYLENEDIOXY)BUTYROPHENONE 63740-97-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
US $40.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
US $0.00 / kg
99%
henan kanbei chemical co.,ltd

3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

63740-97-6(3,4-(METHYLENEDIOXY)BUTYROPHENONE)Related Search:

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ETHYL 4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRATE (2R)-5-BENZYLOXYCARBONYL-8-OXO-6-PHENYL-7,8-DIHYDRO-6H-[1,3]DIOXOLO[4,5-G]QUINOLINE CIS-2-(3,4-METHYLENEDIOXYBENZOYL)CYCLOHEXANE-1-CARBOXYLIC ACID

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3',4'-(Methylenedioxy)butyrophenone, 1-(1,3-Benzodioxol-5-yl)-1-butanone, 5-Butyryl-1,3-benzodioxole 3,4-METHYLENEDIOXYPHENYL-BUTONE 3,4-(METHYLENEDIOXY)BUTYROPHENONE 1,3-BENZODIOXOLE-5-BUTYROYL 1-(1,3-Benzodioxol-5-yl)-1-butanone~5-Butyryl-1,3-benzodioxole 1-(1,3-Benzodioxol-5-yl)-1-butanone 5-Butyryl-1,3-benzodioxole 3'',4''-(METHYLENEDIOXY)BUTYROPHENONE, 98+% 1-Butanone,1-(1,3-benzodioxol-5-yl)- 3'-Chlorobutanophenone 1-(1,3-Benzodioxol-5-yl)- 1-(Benzo[d][1,3]dioxol-5-yl)butan-1-one 1-(1,3-benzodioxol-5-yl)butan-1-one 1-(Benzod1,3dioxol-5-yl)-1-butanone 3',4'-(Methylenedioxy)butyrophenone 63740-97-6 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals