3,4-(Methylenedioxy)butyrophenone
- CAS No.
- 63740-97-6
- Chemical Name:
- 3,4-(Methylenedioxy)butyrophenone
- Synonyms
- 3'-Chlorobutanophenone;1-(1,3-Benzodioxol-5-yl)-;5-Butyryl-1,3-benzodioxole;1,3-BENZODIOXOLE-5-BUTYROYL;3,4-METHYLENEDIOXYPHENYL-BUTONE;3,4-(Methylenedioxy)butyrophenone;1-(1,3-Benzodioxol-5-yl)-1-butanone;1-(1,3-benzodioxol-5-yl)butan-1-one;1-(Benzod1,3dioxol-5-yl)-1-butanone;3',4'-(Methylenedioxy)butyrophenone
- CBNumber:
- CB2482644
- Molecular Formula:
- C11H12O3
- Molecular Weight:
- 192.21
- MDL Number:
- MFCD01075043
- MOL File:
- 63740-97-6.mol
- MSDS File:
- SDS
| Melting point | 47-49°C |
|---|---|
| Boiling point | 319.3±31.0 °C(Predicted) |
| Density | 1.163±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| BRN | 168758 |
| CAS DataBase Reference | 63740-97-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| HS Code | 29329990 |
3,4-(Methylenedioxy)butyrophenone price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM25830 | 3',4'-(Methylenedioxy)butyrophenone | 63740-97-6 | 250mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM25830 | 3',4'-(Methylenedioxy)butyrophenone | 63740-97-6 | 100mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM25830 | 3',4'-(Methylenedioxy)butyrophenone | 63740-97-6 | 50mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM25830 | 3',4'-(Methylenedioxy)butyrophenone | 63740-97-6 | 500mg | $995 | 2026-06-04 | Buy |
| Biosynth | FM25830 | 3',4'-(Methylenedioxy)butyrophenone | 63740-97-6 | 1000mg | $1810 | 2026-06-04 | Buy |
3,4-(Methylenedioxy)butyrophenone Chemical Properties,Uses,Production
Chemical Properties
3,4-(METHYLENEDIOXY)BUTYROPHENONE is White to cream solid
Uses
Used in the synthesis of α-propylpiperonylamine and analogs.
Uses
3,4-(METHYLENEDIOXY)BUTYROPHENONE is used in the synthesis of α-propylpiperonylamine and analogs.
Synthesis
106-31-0
274-09-9
63740-97-6
To a pre-dried two-necked round-bottomed flask were added 1,2-methylenedioxybenzene (piperylene ring, 2.0 g, 16.37 mmol), 1,2-dichloroethane (7 mL) and n-butyric anhydride (3.2 mL, 19.6 mmol). The reaction mixture was cooled to -10 °C and boron trifluoride ethyl ether complex (BF3-Et2O, 6.78 g, 47.7 mmol) was slowly added dropwise over 15 min while keeping the reaction temperature between -5 °C and 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at -5 °C for 3 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium acetate solution, and the organic layer was separated and washed sequentially with 5% aqueous sodium hydroxide solution (7 mL) and deionized water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate (10:1, v/v) as eluent to afford the target compound 3,4-(methylenedioxy)phenylbutanone (1.34 g, 85% yield). 1H NMR (400 MHz, CDCl3) δ: 7.52 (dd, J = 8.1, 1.6 Hz, 1H), 7.40 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 8.1 Hz, 1H), 5.99 (s, 1H), 2.82 (t, J = 7.3 Hz, 2H), 1.70 (h, J = 7.4 Hz, 2H ), 0.95 (t, J = 7.4 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ: 198.4, 151.5, 148.1, 132.0, 124.1, 107.8, 107.7, 101.7, 40.2, 18.0, 13.8. HRMS-ESI-MS (m/z) [M + H]+: calculated value C11H13O3: 193.0865; measured value: 193.0867.
References
[1] Organic Process Research and Development, 2002, vol. 6, # 1, p. 54 - 63
[2] Tetrahedron, 2013, vol. 69, # 1, p. 268 - 273
[3] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 13, p. 2668 - 2674
3,4-(Methylenedioxy)butyrophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
View Lastest Price from 3,4-(Methylenedioxy)butyrophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-15 | 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
|
1KG | 99% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-20 | 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2022-09-27 | 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
|
1kg | 99% | 1000kg | henan kanbei chemical co.,ltd |
-
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
- $40.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 3,4-(METHYLENEDIOXY)BUTYROPHENONE
63740-97-6
- $0.00
- 99%
- henan kanbei chemical co.,ltd
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